Comparison of Subcutaneous and Vaginal Progesterone Used for Luteal Phase Support in Patients Undergoing Intracytoplasmic Sperm Injection Cycles
| Autor: | Nasrin Saharkhiz, Leila Nazari, Sedighe Hosseini, Ali Sobhaneian, Saghar Salehpour |
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| Rok vydání: | 2021 |
| Předmět: |
Pregnancy test
medicine.medical_specialty Pregnancy Rate medicine.medical_treatment 030209 endocrinology & metabolism Fertilization in Vitro Luteal phase Luteal Phase Endometrium ICSI Cyclogest Intracytoplasmic sperm injection 03 medical and health sciences 0302 clinical medicine Patient satisfaction Pregnancy medicine Humans Prospective Studies Sperm Injections Intracytoplasmic ongoing pregnancy Progesterone Fetus 030219 obstetrics & reproductive medicine Assisted reproductive technology Obstetrics business.industry medicine.anatomical_structure Prolutex Gestation clinical pregnancy Female Original Article business |
| Zdroj: | JBRA Assisted Reproduction |
| ISSN: | 1518-0557 |
| Popis: | Objective Luteal phase defect in patients undergoing assisted reproductive technology (ART) is a sign of uterine failure due to insufficient progesterone effects on the endometrium. This study aims to compare the success rate and side effects of subcutaneous progesterone and vaginal progesterone to support the luteal phase in ART cycles. Methods In this prospective randomized study, we used the traditional intracytoplasmic sperm injection (ICSI), and we transferred one or two 4-8 cell fetuses based on the patient's age on the third day of inoculation. We started with luteal phase support from the day of oocyte recovery and the patients randomly received either a daily dose of 25mg subcutaneous progesterone (Prolutex, IBSA Switzerland) or a 400mg dose of vaginal progesterone (Cyclogest, Actoverco, United Kingdom) every 12 hours. If blood BHCG pregnancy test was positive, support for the luteal phase continued until week 10 of gestation. The measured outcomes were the clinical, chemical and ongoing pregnancy rates as well as the rate of early abortion, patients' acceptance, tolerance and satisfaction. Results The results of the present study showed that there was no statistically significant difference between clinical, chemical and ongoing pregnancy rates - as well as the rate of early abortion, and patients' satisfaction when comparing the two treatment Groups. Conclusions it seems that the subcutaneous form of progesterone can be used in patients who are not willing to use vaginal progesterone, with similar treatment results and patient satisfaction, when compared to vaginal progesterone. |
| Databáze: | OpenAIRE |
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