Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing

Autor: Bianca Maria Ciminelli, Patrizia Malaspina, Tullia Di Corcia, Cesar Sanchez Mellado, Carla Jodice, Francesco Messina, Irene Contini, Olga Rickards, Michele Ragazzo
Rok vydání: 2018
Předmět:
0301 basic medicine
Heredity
Urban Population
lcsh:Medicine
Population genetics
Human genetic variation
Biochemistry
Haplogroup
Geographical Locations
Mice
0302 clinical medicine
Peru
lcsh:Science
Geographic Areas
Multidisciplinary
Geography
TOR Serine-Threonine Kinases
Hep G2 Cells
Mitochondrial DNA
Nucleic acids
Europe
Genetic Mapping
Genetic structure
Microsatellite
RNA Interference
geographic locations
Research Article
Urban Areas
Forms of DNA
Protein Serine-Threonine Kinases
Biology
Real-Time Polymerase Chain Reaction
Settore BIO/08
DNA
Mitochondrial
03 medical and health sciences
parasitic diseases
Genetics
Animals
Humans
030216 legal & forensic medicine
Evolutionary Biology
Biology and life sciences
Population Biology
lcsh:R
Haplotype
Genetic Variation
DNA
South America
DNA Fingerprinting
Settore BIO/18 - Genetica
Genetics
Population
030104 developmental biology
Haplotypes
Genetic Loci
Genetic marker
Evolutionary biology
People and Places
Earth Sciences
Haplogroups
lcsh:Q
CRISPR-Cas Systems
Population Genetics
HeLa Cells
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200796 (2018)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0200796
Popis: The human genetic diversity around the world was studied through several high variable genetic markers. In South America the demic consequences of admixture events between Native people, European colonists and African slaves have been displayed by uniparental markers variability. The mitochondrial DNA (mtDNA) has been the most widely used genetic marker for studying American mixed populations, although nuclear markers, such as microsatellite loci (STRs) commonly used in forensic science, showed to be genetically and geographically structured. In this work, we analyzed DNA from buccal swab samples of 296 individuals across Peru: 156 Native Amazons (Ashaninka, Cashibo and Shipibo from Ucayali, Huambiza from Loreto and Moche from Lambayeque) and 140 urban Peruvians from Lima and other 33 urban areas. The aim was to evaluate, through STRs and mtDNA variability, recent migrations in urban Peruvian populations and to gain more information about their continental ancestry. STR data highlighted that most individuals (67%) of the urban Peruvian sample have a strong similarity to the Amazon Native population, whereas 22% have similarity to African populations and only ~1% to European populations. Also the maternally-transmitted mtDNA confirmed the strong Native contribution (~90% of Native American haplogroups) and the lower frequencies of African (~6%) and European (~3%) haplogroups. This study provides a detailed description of the urban Peruvian genetic structure and proposes forensic STRs as a useful tool for studying recent migrations, especially when coupled with mtDNA.
Databáze: OpenAIRE
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