Modification of coronary artery disease progression by cholesterol-lowering therapy: the angiographic studies
| Autor: | Archbold Ra, Timmis Ad |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Coronary angiography
medicine.medical_specialty Endocrinology Diabetes and Metabolism Hypercholesterolemia Coronary Disease Coronary disease Coronary Angiography Coronary artery disease Internal medicine Genetics medicine Humans Molecular Biology Randomized Controlled Trials as Topic Nutrition and Dietetics business.industry Incidence (epidemiology) Anticholesteremic Agents Cholesterol lowering Too slowly Cell Biology medicine.disease Cardiology Statin therapy Cardiology and Cardiovascular Medicine business |
| Zdroj: | Current opinion in lipidology. 10(6) |
| ISSN: | 0957-9672 |
| Popis: | Large randomized placebo-controlled trials have demonstrated that cholesterol lowering with statin therapy reduces the incidence of adverse cardiac events. Smaller angiographic studies have shown that coronary artery disease progression can be slowed and, in some cases, reversed by cholesterol-lowering interventions. These anatomical changes, however, are small and occur too slowly to account for the early clinical benefit. Current evidence suggests that plaque stabilization is the most important mechanism, by which cholesterol-lowering therapy reduces both the incidence of adverse cardiac events and coronary artery disease progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|