Action of surfactants on the mammal epidermal skin barrier
| Autor: | Clara Barba, Luisa Coderch, Alessandra Semenzato, Gianni Baratto |
|---|---|
| Přispěvatelé: | Ministerio de Educación y Ciencia (España), Barba, Clara, Barba, Clara [0000-0002-3084-2925] |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Skin barrier
Swine Skin Absorption Surfactants Detergents Human skin Dermatology Permeability Cornea 030207 dermatology & venereal diseases 03 medical and health sciences Surface-Active Agents 0302 clinical medicine Pulmonary surfactant Desorption SC lipid Stratum corneum Medicine Animals Alkyl Skin chemistry.chemical_classification integumentary system business.industry Lipid Metabolism Shampoo medicine.anatomical_structure chemistry Permeability (electromagnetism) Models Animal Biophysics Epidermis business |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | BACKGROUND: Daily skin washing routines can promote undesirable effects on skin barrier function. The stratum corneum (SC) lipid matrix is crucial for skin barrier function. Skin cleansing products are mostly composed of surfactants: surface-active molecules that interact with skin lipids in several ways. The main aim of this work was to investigate the effect produced by surfactants on skin barrier permeability. Porcine skin is a well-accepted and readily available model of the human skin barrier. The effect of two cleansing formulations (based on different surfactant mixtures) on the barrier properties of mammalian skin were evaluated. METHODS: Water sorption/desorption (DVS) experiments were used to measure skin permeability. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy and confocal Raman were useful to study SC lipid organization. RESULTS: The results showed that while anionic surfactants (SLS) had a negative impact on the skin barrier, with a clear increase of alkyl chain disorder; cosurfactants present in the shampoo formulation diminished the detrimental effect of their primary ionic surfactant, inducing less modification on lipid intramolecular chain disorder. CONCLUSIONS: The obtained results confirmed that the mild cleansing formulations studied had gentle interaction with skin. The capacity to discriminate between detergent systems was clearly established with both DVS and spectroscopy techniques. The authors wish to thank the Spanish National Projects (Ministerio de Educación y Ciencia) CTQ2013-44998-P and 2014 SGR 1325 (AGAUR) for financial support. The authors are grateful to Montserrat Rigol Muxart and Núria Solanes Batlló from the Department of Cardiology (Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Hospital Clínic, Universitat de Barcelona, Spain) for supplying porcine skin biopsies and J. Carilla for their expert assistance with the techniques used in this work. |
| Databáze: | OpenAIRE |
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