Composite chitosan/alginate hydrogel for controlled release of deferoxamine: A system to potentially treat iron dysregulation diseases

Autor: Elisabetta Gavini, Marta Roldo, Elena Piera Porcu, Giovanna Rassu, Paolo Giunchedi, Andrea Salis
Rok vydání: 2016
Předmět:
Polymers and Plastics
Chemistry
Pharmaceutical
Pharmacy
02 engineering and technology
PLGA microparticles
01 natural sciences
Chitosan
chemistry.chemical_compound
Glucuronic Acid
Polylactic Acid-Polyglycolic Acid Copolymer
Materials Chemistry
Drug Carriers
Viscosity
Hexuronic Acids
Hydrogels
021001 nanoscience & nanotechnology
Controlled release
Microspheres
Deferoxamine
Self-healing hydrogels
0210 nano-technology
Drug carrier
Porosity
medicine.drug
Iron dysregulation diseases
Drug Liberation
Alginates
Iron
macromolecular substances
Absorption (skin)
010402 general chemistry
complex mixtures
Metabolic Diseases
medicine
Lactic Acid
Particle Size
Composite hydrogel
business.industry
Alginate
Organic Chemistry
technology
industry
and agriculture
Glucuronic acid
0104 chemical sciences
Biotechnology
chemistry
Chemical engineering
Delayed-Action Preparations
business
Polyglycolic Acid
Zdroj: Rassu, G, Salis, A, Porcu, E P, Giunchedi, P, Roldo, M & Gavini, E 2016, ' Composite chitosan/alginate hydrogel for controlled release of deferoxamine : a system to potentially treat iron dysregulation diseases ', Carbohydrate Polymers, vol. 136, pp. 1338-1347 . https://doi.org/10.1016/j.carbpol.2015.10.048
ISSN: 0144-8617
Popis: Recently, the potential application of deferoxamine (DFO) in several iron dysregulation diseases has been highlighted. However, DFO presents significant limitations in clinical use due to its poor absorption in the gut and very short plasma half-life. To overcome these problems, the feasibility of chitosan/alginate hydrogels as prolonged delivery systems of DFO was investigated. Hydrogel alone or co-formulated with poly(D,L-lactide-co-glycolide) microspheres were prepared and studied in vitro. The influence of the preparation methods on the performance of composite hydrogels on controlled DFO release was explored. Spray-dried microspheres based on poly(D,L-lactide-co-glycolide) were able to encapsulate DFO, a highly water soluble drug. Nevertheless, only the composite hydrogels managed to provide sustained drug release. The inclusion of microspheres into pre-formed chitosan/alginate hydrogel provided the most efficient delivery system; the drug released from microspheres is strongly entrapped in the hydrogel network and slowly released by diffusion.
Databáze: OpenAIRE
Externí odkaz: