Composite chitosan/alginate hydrogel for controlled release of deferoxamine: A system to potentially treat iron dysregulation diseases
Autor: | Elisabetta Gavini, Marta Roldo, Elena Piera Porcu, Giovanna Rassu, Paolo Giunchedi, Andrea Salis |
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Rok vydání: | 2016 |
Předmět: |
Polymers and Plastics
Chemistry Pharmaceutical Pharmacy 02 engineering and technology PLGA microparticles 01 natural sciences Chitosan chemistry.chemical_compound Glucuronic Acid Polylactic Acid-Polyglycolic Acid Copolymer Materials Chemistry Drug Carriers Viscosity Hexuronic Acids Hydrogels 021001 nanoscience & nanotechnology Controlled release Microspheres Deferoxamine Self-healing hydrogels 0210 nano-technology Drug carrier Porosity medicine.drug Iron dysregulation diseases Drug Liberation Alginates Iron macromolecular substances Absorption (skin) 010402 general chemistry complex mixtures Metabolic Diseases medicine Lactic Acid Particle Size Composite hydrogel business.industry Alginate Organic Chemistry technology industry and agriculture Glucuronic acid 0104 chemical sciences Biotechnology chemistry Chemical engineering Delayed-Action Preparations business Polyglycolic Acid |
Zdroj: | Rassu, G, Salis, A, Porcu, E P, Giunchedi, P, Roldo, M & Gavini, E 2016, ' Composite chitosan/alginate hydrogel for controlled release of deferoxamine : a system to potentially treat iron dysregulation diseases ', Carbohydrate Polymers, vol. 136, pp. 1338-1347 . https://doi.org/10.1016/j.carbpol.2015.10.048 |
ISSN: | 0144-8617 |
Popis: | Recently, the potential application of deferoxamine (DFO) in several iron dysregulation diseases has been highlighted. However, DFO presents significant limitations in clinical use due to its poor absorption in the gut and very short plasma half-life. To overcome these problems, the feasibility of chitosan/alginate hydrogels as prolonged delivery systems of DFO was investigated. Hydrogel alone or co-formulated with poly(D,L-lactide-co-glycolide) microspheres were prepared and studied in vitro. The influence of the preparation methods on the performance of composite hydrogels on controlled DFO release was explored. Spray-dried microspheres based on poly(D,L-lactide-co-glycolide) were able to encapsulate DFO, a highly water soluble drug. Nevertheless, only the composite hydrogels managed to provide sustained drug release. The inclusion of microspheres into pre-formed chitosan/alginate hydrogel provided the most efficient delivery system; the drug released from microspheres is strongly entrapped in the hydrogel network and slowly released by diffusion. |
Databáze: | OpenAIRE |
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