Iatrogenic hypomagnesemia: an underestimated clinical problem
| Autor: | Gabriella Nucera, Paolo Zanada, Antonio Villa, Francesca Campanini, Elena Martinoli, Annamaria Boschiero, Adriana Pellegrino |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
endocrine system Population lcsh:Medicine Gastroenterology Hypomagnesemia Internal medicine diuretics medicine education education.field_of_study business.industry lcsh:R Retrospective cohort study General Medicine Magnesium level medicine.disease Metformin Surgery Concomitant Vomiting Proton pump inhibitor therapy medicine.symptom proton pump inhibitors business metformin medicine.drug |
| Zdroj: | Italian Journal of Medicine, Vol 9, Iss 3, Pp 287-289 (2015) |
| ISSN: | 1877-9352 1877-9344 |
| Popis: | Hypomagnesemia is defined by having a serum magnesium level of less than 1.7 mg/dL. The magnesium balance is tightly regulated by the concerted actions of the intestine, bone and kidneys. This balance can be disturbed by a wide variety of drugs. Recently, we observed a case of severe hypomagnesemia caused by proton pump inhibitor therapy. We conducted a retrospective study of an intrahospital population to evaluate the prevalence of hypomagnesemia and the relationship with associated drugs. Among 181 patients with hypomagnesemia only 29 were found to have hypomagnesemia with specific causes, such as chronic diarrhea, vomiting, and so on. In the remaining patients, 120 have taken proton pump inhibitors and/or diuretics and/or metformin. Clinicians should consider proton pump inhibitors as a possible causative agent when investigating hypomagnesemia and they should be especially attentive with patients who take proton pump inhibitors, especially in cases of long-term therapy (≥1 year) and/or concomitant administration of other agents that may lower magnesium levels (e.g., diuretics or metformin). |
| Databáze: | OpenAIRE |
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