New Insights Into Permeation of Large Cations Through ATP-Gated P2X Receptors
Autor: | Kate Dunning, Thomas Grutter, Juline Beudez, Thierry Chataigneau, Laurie Peverini |
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Přispěvatelé: | Conception et application de molécules bioactives (CAMB), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Ion permeation P2X receptors [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Review LGICs lcsh:RC321-571 [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biophysics 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology Mechanism (philosophy) spermidine Economics dilation ion permeation Molecular Biology Neuroscience lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ComputingMilieux_MISCELLANEOUS |
Zdroj: | Frontiers in Molecular Neuroscience Frontiers in Molecular Neuroscience, Frontiers Media, 2018, 11, ⟨10.3389/fnmol.2018.00265⟩ Frontiers in Molecular Neuroscience, Vol 11 (2018) |
ISSN: | 1662-5099 |
Popis: | The permeability of large cations through the P2X pore has remained arguably the most controversial and complicated topic in P2X-related research, with the emergence of conflicting studies on the existence, mechanism and physiological relevance of a so-called “dilated” state. Due to the important role of several “dilating” P2X subtypes in numerous diseases, a clear and detailed understanding of this phenomenon represents a research priority. Recent advances, however, have challenged the existence of a progressive, ATP-induced pore dilation, by demonstrating that this phenomenon is an artifact of the method employed. Here, we discuss briefly the history of this controversial and enigmatic dilated state, from its initial discovery to its recent reconsideration. We will discuss the literature in which mechanistic pathways to a large cation-permeable state are proposed, as well as important advances in the methodology employed to study this elusive state. Considering recent literature, we will also open the discussion as to whether an intrinsically dilating P2X pore exists, as well as the physiological relevance of such a large cation-permeable pore and its potential use as therapeutic pathway. |
Databáze: | OpenAIRE |
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