Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats
| Autor: | Valentina De Castro, Viviana Trezza, Benno Roozendaal, Maria Morena, Patrizia Campolongo, Matthew N. Hill, Maura Palmery, J. Megan Gray |
|---|---|
| Přispěvatelé: | Morena, Maria, De Castro, Valentina, Gray, J. Megan, Palmery, Maura, Trezza, Viviana, Roozendaal, Benno, Hill, Matthew N, Campolongo, Patrizia |
| Rok vydání: | 2015 |
| Předmět: |
Male
Cannabinoid receptor Emotions Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] cannabinoid receptors emotional arousal endocannabinoids memory for emotional experiences stress neuroscience (all) Hippocampus Water maze Developmental psychology Rats Sprague-Dawley chemistry.chemical_compound Enzyme Inhibitors JZL184 memory for emotional experience General Neuroscience Temperature Articles Calcium Channel Blockers Endocannabinoid system Benzamides lipids (amino acids peptides and proteins) Arousal Psychology Neuroinformatics Morpholines Spatial Learning Effects of stress on memory Neurophysiology Arachidonic Acids Naphthalenes Glycerides Animals Maze Learning Cannabinoid Receptor Agonists Dose-Response Relationship Drug Recall cannabinoid receptor endocannabinoid URB597 Benzoxazines Rats chemistry Mental Recall Carbamates Corticosterone Neuroscience Stress Psychological Endocannabinoids |
| Zdroj: | The Journal of Neuroscience, 35, 13962-74 The Journal of Neuroscience, 35, 41, pp. 13962-74 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | Contains fulltext : 150747.pdf (Publisher’s version ) (Open Access) Variations in environmental aversiveness influence emotional memory processes in rats. We have previously shown that cannabinoid effects on memory are dependent on the stress level at the time of training as well as on the aversiveness of the environmental context. Here, we investigated whether the hippocampal endocannabinoid system modulates memory retrieval depending on the training-associated arousal level. Male adult Sprague Dawley rats were trained on a water maze spatial task at two different water temperatures (19 degrees C and 25 degrees C) to elicit either higher or lower stress levels, respectively. Rats trained under the higher stress condition had better memory and higher corticosterone concentrations than rats trained at the lower stress condition. The cannabinoid receptor agonist WIN55212-2 (10-30 ng/side), the 2-arachidonoyl glycerol (2-AG) hydrolysis inhibitor JZL184 (0.1-1 mug/side), and the anandamide (AEA) hydrolysis inhibitor URB597 (10-30 ng/side) were administered bilaterally into the hippocampus 60 min before probe-trial retention testing. WIN55212-2 or JZL184, but not URB597, impaired probe-trial performances only of rats trained at the higher stressful condition. Furthermore, rats trained under higher stress levels displayed an increase in hippocampal 2-AG, but not AEA, levels at the time of retention testing and a decreased affinity of the main 2-AG-degrading enzyme for its substrate. The present findings indicate that the endocannabinoid 2-AG in the hippocampus plays a key role in the selective regulation of spatial memory retrieval of stressful experience, shedding light on the neurobiological mechanisms involved in the impact of stress effects on memory processing. SIGNIFICANCE STATEMENT: Endogenous cannabinoids play a central role in the modulation of memory for emotional events. Here we demonstrate that the endocannabinoid 2-arachidonoylglycerol in the hippocampus, a brain region crucially involved in the regulation of memory processes, selectively modulates spatial memory recall of stressful experiences. Thus, our findings provide evidence that the endocannabinoid 2-arachidonoylglycerol is a key player in mediating the impact of stress on memory retrieval. These findings can pave the way to new potential therapeutic intervention for the treatment of neuropsychiatric disorders, such as post-traumatic stress disorder, where a previous exposure to traumatic events could alter the response to traumatic memory recall leading to mental illness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|