Incremental Peritoneal Dialysis May be Beneficial for Preserving Residual Renal Function Compared to Full-dose Peritoneal Dialysis
Autor: | Hyunjin Ryu, Seokwoo Park, Hajeong Lee, Yeonhee Lee, Joongyub Lee, Kwon Wook Joo, Dong Ki Kim, Sung Won Chung, Curie Ahn, Kook Hwan Oh |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.medical_treatment Peritoneal dialysis Urology Renal function lcsh:Medicine Peritonitis Lower risk Anuria Article 03 medical and health sciences End-stage renal disease 0302 clinical medicine Medicine Humans lcsh:Science Dialysis Retrospective Studies Multidisciplinary business.industry Hazard ratio lcsh:R Middle Aged Confidence interval 030104 developmental biology Propensity score matching Kidney Failure Chronic Female lcsh:Q medicine.symptom business 030217 neurology & neurosurgery Glomerular Filtration Rate |
Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Maintaining residual renal function (RRF) is a crucial issue in peritoneal dialysis (PD). Incremental dialysis is the practice of initiating PD exchanges less than four times a day in consideration of RRF, and increasing dialysis dose in a step-wise manner as the RRF decreases. We aimed to compare the outcomes of incremental PD and full-dose PD in terms of RRF preservation and other outcomes. This was a single-center, observational study. Data were extracted retrospectively from a cohort of incident PD patients over 16 years old who started PD between 2007 and 2015 in the PD Unit of Seoul National University Hospital. We used inverse probability weighting (IPW) adjustment based on propensity scores to balance covariates between the incremental and full-dose PD groups. Multivariate, time-dependent Cox analyses were performed. Among 347 incident PD patients, 176 underwent incremental PD and 171 underwent conventional full-dose PD. After IPW adjustment, the incremental PD group exhibited a lower risk of developing anuria (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.43–0.88). Patient survival, technique survival, and peritonitis-free survival were all similar between these groups (P > 0.05 by log-rank test). Incremental PD was beneficial for preserving RRF and showed similar patient survival when compared to conventional full-dose PD. |
Databáze: | OpenAIRE |
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