Interaction of Skeletal and Left Ventricular Mass in Older Adults with Low Muscle Performance
| Autor: | Mauro Di Bari, Luna Zerbinati, Riccardo Calvani, Sara Tagliaferri, Matteo Cesari, Antonio Cherubini, Yari Longobucco, Emanuele Marzetti, Giacomo Bussolati, Elisa Adorni, Roberto Bernabei, Felice Perrino, Francesco Landi, Fulvio Lauretani, Giovanna Pelà, Marcello Maggio |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cardiac output Population low physical performance 030204 cardiovascular system & hematology left ventricular mass 03 medical and health sciences 0302 clinical medicine Internal medicine SPRINT-T medicine education Body surface area education.field_of_study business.industry Confounding Settore MED/09 - MEDICINA INTERNA skeletal muscle mass medicine.disease Blood pressure Sarcopenia Cardiology Lean body mass Geriatrics and Gerontology business Body mass index 030217 neurology & neurosurgery |
| Popis: | BACKGROUND It was recently hypothesized the existence of "cardiac-skeletal muscle axis." However, the relationship between skeletal muscle mass (SMM) and left ventricular mass (LVM) has never been investigated in the specific group of older individuals with low skeletal mass and physical performance. We tested this hypothesis in the SPRINT-T (Sarcopenia and Physical Frailty IN older people: multicomponenT Treatment strategies Trial) population using LVM as independent variable and SMM as dependent variable. METHODS SMM was assessed by dual-energy X-ray absorptiometry scan and expressed as appendicular lean mass (ALM), and LVM was estimated through echocardiography. Low ALM was defined according to Foundation for the National Institutes of Health Sarcopenia Project criteria, and Short Physical Performance Battery (SPPB) was used to assess physical performance. RESULTS The population consisted of 100 persons (33 men and 67 women), aged 70 years or older (mean age = 79 ± 5 years) with low ALM and SPPB ranged between 3 and 9, suggestive of physical frailty. Charlson Comorbidity Index median score was 0. Mean value of LVM was 193 ± 67 g, indexed LVM/body surface area (LVM/BSA) was 112 ± 33 g/m2, and cardiac output (CO) was 65 ± 19 L/min. ALM was strongly and positively correlated with LVM (r = 0.54602; P |
| Databáze: | OpenAIRE |
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