Activation of calcium-ATPase of liver plasma membrane by dextran sulfates
| Autor: | Setsuo Tomizawa, Kyoichi Kagawa |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Chemistry
Cell Membrane Biophysics Dextrans Cell Biology Calcium-Transporting ATPases Biochemistry Rats Calcium ATPase Enzyme Activation chemistry.chemical_compound Kinetics Dextran sulfate Dextran Membrane Liver Rat liver Sulfur content Molar mass distribution Animals Female Molecular Biology Protein Binding |
| Zdroj: | Biochemical and biophysical research communications. 86(3) |
| ISSN: | 0006-291X |
| Popis: | Dextran sulfate (DS) with average molecular weight (AMW) of 20,000 and sulfur content of 18%, which has a high lipemia clearing activity, enhanced Ca2+ binding to the plasma membrane of rat liver, and the DS itself bound the membrane, whereas there was little binding of DS and Ca2+. Various DSs slightly activated Na+-K+-ATPase, but not Mg2+-ATPase activity of the membrane. These results suggest that DSs, especially with high AMW of 20,000, bind the plasma membrane, resulting in enhancements of the Ca2+ binding to there and Ca2+-ATPase activity. |
| Databáze: | OpenAIRE |
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