Time modulation of spike-and-wave activity in generalized epilepsy
| Autor: | James D. Frost, James W. Crawley, Peter Kellaway |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Audiology Biology Time pattern Modulation (music) Random pattern medicine Humans Ictal Generalized epilepsy Child Evoked Potentials Epilepsy Phase angle Spike-and-wave Electroencephalography medicine.disease Circadian Rhythm Ethosuximide Neurology Anesthesia Child Preschool Anticonvulsants Neurology (clinical) Sleep Stages Arousal medicine.drug |
| Zdroj: | Annals of neurology. 8(5) |
| ISSN: | 0364-5134 |
| Popis: | Nineteen patients, aged 4 to 44 years, with generalized epilepsy and generalized 3 Hz spike-and-wave activity, were monitored for 24 or 36 hours on one to nine occasions to determine the time distribution of ictal and interictal electroencephalographic discharges and the consistency of the time patterns observed. Two patients with a low incidence of spike-and-wave activity had a random pattern of occurrence; the other 17 showed one of three types of time modulation. The latter can be explained by the interaction of two modulative processes, one with a period of about 100 minutes and the other of approximately 24 hours. The pattern observed depends on the phase angle of the two cyclic processes. Treatment with ethosuximide altered the pattern of time modulation, and eventually, when the spike-and-wave activity was reduced to a low level, the time distribution became random. |
| Databáze: | OpenAIRE |
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