Prognostic and predictive biomarkers of abdominal aortic aneurysm growth rate
Autor: | Jan H.N. Lindeman, Lai Shan Chan, C. Arnoud Meijer, Lei Shen, Mark A. Deeg |
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Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Pathology Apolipoprotein B macromolecular substances 030204 cardiovascular system & hematology Placebo Gastroenterology 03 medical and health sciences 0302 clinical medicine Aneurysm Internal medicine medicine Humans Aged Retrospective Studies Doxycycline Aged 80 and over Inflammation Univariate analysis biology business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease Abdominal aortic aneurysm 030104 developmental biology cardiovascular system biology.protein Female business Elastin Biomarkers medicine.drug Aortic Aneurysm Abdominal |
Zdroj: | Current Medical Research and Opinion, 32(3), 509-517 |
ISSN: | 1473-4877 |
Popis: | Objectives: To test the utility of clinical and circulating biomarkers to predict abdominal aortic aneurysm (AAA) growth rate and response to doxycycline therapy. Methods: Plasma samples were obtained in the Pharmaceutical Aneurysm Stabilization Trial that tested the effect of doxycycline (n = 44) vs. placebo (n = 49) in patients with a 35–50 mm AAA. Approximately 200 biomarkers were evaluated in a candidate approach that included markers of matrix turnover and cathepsin S activity and a broad-based approach of predominantly inflammation-related and clinical biomarkers. Results: In a recursive partitioning based analysis, total cholesterol, baseline AAA size, and apolipoprotein B were prognostic of AAA growth in the placebo group whereas elastin and biglycan degradation products were predictive of AAA growth with doxycycline treatment. Univariate analysis of these biomarkers showed that baseline total cholesterol (r = 0.38, unadjusted P = 0.011), apolipoprotein B (r = 0.41, unadjusted P = 0.005), and baseline AAA size (r = 0.35, unadjusted P = 0.013) correlated with AAA growth in the placebo but not the doxycycline group. Elastin fragments were associated with 18 month AAA growth (r = 0.33, unadjusted P = 0.031) in the doxycycline group. Limitations: Limitations of this study include small sample size, a retrospective growth analysis, and translatability of the method used to measure the analytes. Conclusions: This study implies that total cholesterol, baseline AAA size, and apolipoprotein B are predictors of AAA growth. Levels of elastin and biglycan fragments are predictive of doxycycline effects on AAA growth and provide a clue towards this unexpected negative effect. |
Databáze: | OpenAIRE |
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