Prognostic value of visit-to-visit systolic blood pressure variability related to diabetic kidney disease among patients with type 2 diabetes
| Autor: | Zhebin Yu, Kun Chen, Hongbo Lin, Xue-Yu Chen, Jianbing Wang, Die Li |
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| Rok vydání: | 2019 |
| Předmět: |
Male
China medicine.medical_specialty endocrine system diseases Systole Physiology Blood Pressure Disease Type 2 diabetes 030204 cardiovascular system & hematology Risk Assessment Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans Diabetic Nephropathies 030212 general & internal medicine Aged Proportional Hazards Models Retrospective Studies business.industry Incidence nutritional and metabolic diseases Type 2 Diabetes Mellitus Blood Pressure Determination Retrospective cohort study Middle Aged Prognosis medicine.disease Blood pressure Diabetes Mellitus Type 2 Hypertension Female Cardiology and Cardiovascular Medicine Risk assessment business Algorithms |
| Zdroj: | Journal of Hypertension. 37:1411-1418 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/hjh.0000000000002038 |
| Popis: | This study aimed to evaluate the impact of visit-to-visit variability (VVV) of blood pressure on the risk of diabetic nephropathy and whether it provides additional predictive information among patients with type 2 diabetes mellitus (T2DM) in China.We included 12 630 T2DM patients during January 2008-December 2012 using a retrospective cohort design. VVV of SBP was assessed as standard deviation, coefficient of variation and variation independent of mean of the blood pressure readings during the measurement period. Hazard ratios and 95% confidence intervals were estimated for the associations of variability in SBP with risk of diabetes nephropathy by using Cox proportional hazards regression models. Risk prediction ability was assessed using C statistic, integrated discrimination improvement (IDI) and net reclassification index (NRI).We found a dose-response relationship across quartiles of VVV SBP (P trend 0.001). Hazard ratio in the highest quartile of SD SBP (≥9.2 mmHg) was 1.49 (1.16-1.93) as compared with the lowest quartile (4.8 mmHg) after adjusted for mean SBP values, max SBP values and other covariates. Addition of SD SBP significantly improved risk prediction for diabetic kidney disease (DKD) [C statistic (from 0.664 to 0.673), IDI (0.0011, 95% CI: 0.0003-0.0104) and NRI (0.053, 95% CI: 0.0017-0.113)]. Results remained similar across different subgroups, sensitivity analyses or using coefficient of variation and variance independent of mean.VVV of SBP is a significant risk factor of DKD among T2DM patients on top of mean and max BP values, which provides additional significant predictive information. |
| Databáze: | OpenAIRE |
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