Patterns of Change in the Early (20-Minute) Radioiodine Uptake during Carbimazole Treatment for Graves' Disease and Their Relationship to Outcome *
| Autor: | J. Swanson Beck, T.J. Wilkin, A. Gunn, T. E. Isles, J. Crooks |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Carbimazole Radioiodine uptake Endocrinology Diabetes and Metabolism Graves' disease Clinical Biochemistry Biochemistry Iodine Radioisotopes Endocrinology Internal medicine Humans Medicine Euthyroid Triiodothyronine business.industry Biochemistry (medical) Thyroid Middle Aged Prognosis medicine.disease Graves Disease Kinetics medicine.anatomical_structure Disease remission Female business medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 52:1067-1072 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-52-6-1067 |
| Popis: | The early (20-minute) radioiodine uptake has been used to follow the month by month variations in thyroid stimulation occurring in 35 Graves' disease patients treated with carbimazole and T3 for a period of 18 months. T3 alone (classical suppression test) produced no change in mean uptake, but 4 weeks after the introduction of carbimazole, the mean uptake had fallen from 21.6% to 13.4% of the dose (P < 0.001). Over the subsequent 17 months, the mean uptake fell further to 8% (P < 0.05). Six months after withdrawal of treatment, 20 patients (group R) had relapsed and 15 (group E) had remained euthyroid. The only difference in mean uptake behavior between R and E patients was one of degree, their slopes being similar. Thus while the mean uptake of both groups fell progressively towards normal, that of group E patients arrived much earlier. The uptake in 16 patients fell by greater than 50% by month 2, and 10 of them were from group E. In the remaining 19 patients, the uptake fell less rapidly: only 5 of the... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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