Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli
| Autor: | Oliver Tuescher, Joseph E. LeDoux, Jane Epstein, Hong Pan, Bruce S. McEwen, Emily Stern, James C. Root, Michelle T. Pavony, Michael Gordon Silverman, Marylene Cloitre, Martin Goldstein, Daniel S. Weisholtz, Tracy Butler, Margaret Altemus, David Silbersweig, Amy Cunningham-Bussel |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cortisol secretion medicine.medical_specialty Cortisol awakening response Hydrocortisone Endocrinology Diabetes and Metabolism Hippocampus Amygdala Article Endocrinology Limbic system Internal medicine Limbic System Reaction Time medicine Humans Biological Psychiatry Behavior Brain Mapping Endocrine and Autonomic Systems Magnetic Resonance Imaging Circadian Rhythm Frontal Lobe Psychiatry and Mental health medicine.anatomical_structure Hypothalamus Female September 11 Terrorist Attacks Psychology Neuroscience Photic Stimulation Stress Psychological Glucocorticoid medicine.drug |
| Zdroj: | Psychoneuroendocrinology. 34:694-704 |
| ISSN: | 0306-4530 |
| DOI: | 10.1016/j.psyneuen.2008.11.011 |
| Popis: | The development and exacerbation of many psychiatric and neurologic conditions are associated with dysregulation of the hypothalamic pituitary adrenal (HPA) axis as measured by aberrant levels of cortisol secretion. Here we report on the relationship between the amplitude of diurnal cortisol secretion, measured across 3 typical days in 18 healthy individuals, and blood oxygen level dependant (BOLD) response in limbic fear/stress circuits, elicited by in-scanner presentation of emotionally negative stimuli, specifically, images of the World Trade Center (WTC) attack. Results indicate that subjects who secrete a greater amplitude of cortisol diurnally demonstrate less brain activation in limbic regions, including the amygdala and hippocampus/parahippocampus, and hypothalamus during exposure to traumatic WTC-related images. Such initial findings can begin to link our understanding, in humans, of the relationship between the diurnal amplitude of a hormone integral to the stress response, and those neuroanatomical regions that are implicated as both modulating and being modulated by that response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect