High-fat diet exacerbates SIV pathogenesis and accelerates disease progression
| Autor: | Noah Krampe, Ellen P. Penn, Ivona Pandrea, Kevin D. Raehtz, Daniel N. Frank, Tiffany R Butterfield, Stephanie M. Dillon, William M. McFadden, Alan L. Landay, Russell P. Tracy, Elizabeth Falwell, Tianyu He, Cara C. Wilson, Kathryn J. Martin, Cristian Apetrei, George S. Haret-Richter, Ruy M. Ribeiro, Tammy Dunsmore, Paola Sette, Cuiling Xu, Benjamin B. Policicchio |
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| Přispěvatelé: | Repositório da Universidade de Lisboa |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
animal diseases education Adaptive immunity Simian Acquired Immunodeficiency Syndrome Adipose tissue Inflammation Systemic inflammation Diet High-Fat AIDS/HIV Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Fibrosis Chlorocebus aethiops medicine Animals business.industry digestive oral and skin physiology nutritional and metabolic diseases virus diseases food and beverages General Medicine Cardiovascular disease medicine.disease Acquired immune system Cholesterol 030104 developmental biology Adipose Tissue Liver Cardiovascular Diseases 030220 oncology & carcinogenesis Bacterial Translocation Immunology Disease Progression Liver function medicine.symptom business Research Article |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 1558-8238 |
| Popis: | Copyright: © 2019. American Society for Clinical Investigation. Consuming a high-fat diet (HFD) is a risk factor for obesity and diabetes; both of these diseases are also associated with systemic inflammation, similar to HIV infection. A HFD induces intestinal dysbiosis and impairs liver function and coagulation, with a potential negative impact on HIV/SIV pathogenesis. We administered a HFD rich in saturated fats and cholesterol to nonpathogenic (African green monkeys) and pathogenic (pigtailed macaques) SIV hosts. The HFD had a negative impact on SIV disease progression in both species. Thus, increased cell-associated SIV DNA and RNA occurred in the HFD-receiving nonhuman primates, indicating a potential reservoir expansion. The HFD induced prominent immune cell infiltration in the adipose tissue, an important SIV reservoir, and heightened systemic immune activation and inflammation, altering the intestinal immune environment and triggering gut damage and microbial translocation. Furthermore, HFD altered lipid metabolism and HDL oxidation and also induced liver steatosis and fibrosis. These metabolic disturbances triggered incipient atherosclerosis and heightened cardiovascular risk in the SIV-infected HFD-receiving nonhuman primates. Our study demonstrates that dietary intake has a discernable impact on the natural history of HIV/SIV infections and suggests that dietary changes can be used as adjuvant approaches for HIV-infected subjects, to reduce inflammation and the risk of non-AIDS comorbidities and possibly other infectious diseases. This study was funded through NIH/NHLBI/NIAID/NIDDK/ NCRR R01 grants HL117715 (to IP), HL123096 (to IP), AI119346 (to CA), DK113919 (to IP and CA), DK119936 (to CA), RR025781 (to CA and IP), and AI104373 (to RMR). RMR was funded by grant PTDC/ MAT-APL/31602/2017 from the Fundação para a Ciência e Tecnologia (Portugal). DNF and CCW were supported by the University of Colorado GI and Liver Innate Immunity Program. KDR and BBP were partly supported by the NIH Training Grant T32AI065380. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Databáze: | OpenAIRE |
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