Lung hyperinflation and functional exercise capacity in patients with COPD – a three-year longitudinal study

Autor: Birgitte Espehaug, Jon A. Hardie, Bente Frisk, Per Bakke, Linn T. Aalstad, Einar Thorsen, Tomas Mikal Eagan
Rok vydání: 2018
Předmět:
Male
Lung hyperinflation
Vital capacity
Cohort Studies
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
Risk Factors
Medicine
Mass index
Lung volumes
Longitudinal Studies
Prospective Studies
030212 general & internal medicine
Prospective cohort study
COPD
Exercise Tolerance
Norway
IC/TLC ratio
Middle Aged
respiratory system
Prognosis
Obstructive lung disease
Cardiology
Regression Analysis
Female
medicine.symptom
Lung Volume Measurements
Research Article
Adult
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Walk Test
Exercise intolerance
Time
Functional exercise capacity
03 medical and health sciences
FEV1/FVC ratio
Internal medicine
Humans
6-min walk distance
Exercise
Aged
lcsh:RC705-779
business.industry
Patient Acuity
lcsh:Diseases of the respiratory system
medicine.disease
respiratory tract diseases
030228 respiratory system
Exercise Test
business
Zdroj: BMC Pulmonary Medicine
BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-9 (2018)
ISSN: 1471-2466
DOI: 10.1186/s12890-018-0747-9
Popis: Background: Lung hyperinflation contributes to dyspnea, morbidity and mortality in chronic obstructive pulmonary disease (COPD). The inspiratory-to-total lung capacity (IC/TLC) ratio is a measure of lung hyperinflation and is associated with exercise intolerance. However, knowledge of its effect on longitudinal change in the 6-min walk distance (6MWD) in patients with COPD is scarce. We aimed to study whether the IC/TLC ratio predicts longitudinal change in 6MWD in patients with COPD. Methods: This prospective cohort study included 389 patients aged 40–75 years with clinically stable COPD in Global Initiative for Chronic Obstructive Lung Disease stages II-IV. The 6MWD was measured at baseline, and after one and 3 years. We performed generalized estimating equation regression analyses to examine predictors for longitudinal change in 6MWD. Predictors at baseline were: IC/TLC ratio, age, gender, pack years, fat mass index (FMI), fat-free mass index (FFMI), number of exacerbations within 12 months prior to inclusion, Charlson index for comorbidities, forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and light and hard self-reported physical activity. Results: Reduced IC/TLC ratio (p
Databáze: OpenAIRE
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