Nitric oxide and asymmetric dimethyl arginine (ADMA) levels in an experimental hydronephrotic kidney caused by unilateral partial ureteral obstruction
| Autor: | Hasan Anıl Kurt, Ahmet Reşit Ersay, Dilek Ulker Cakir, Cabir Alan, Naci Topaloğlu, Gokhan Basturk |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Urology 030232 urology & nephrology Renal function Enzyme-Linked Immunosorbent Assay Hydronephrosis 030204 cardiovascular system & hematology lcsh:RC870-923 Arginine Kidney Nitric Oxide urologic and male genital diseases medicine.disease_cause Nitric oxide Rats Sprague-Dawley Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ureter Reference Values Fibrosis medicine Animals Nitrates Paraffin Embedding Superoxide Dismutase business.industry lcsh:Diseases of the genitourinary system. Urology medicine.disease Obstructive Nephropathy Rats Surgery Disease Models Animal Oxidative Stress medicine.anatomical_structure chemistry Original Article business Renal pelvis Oxidative stress Ureteral Obstruction |
| Zdroj: | International braz j urol v.42 n.3 2016 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology International Brazilian Journal of Urology, Vol 42, Iss 3, Pp 614-620 (2016) International braz j urol, Volume: 42, Issue: 3, Pages: 614-620, Published: JUN 2016 |
| ISSN: | 1677-5538 |
| DOI: | 10.1590/s1677-5538.ibju.2015.0030 |
| Popis: | Aim Our aim is to measure asymmetric dimethyl arginine and nitric oxide levels in rats with induced unilateral acute ureteral obstruction to research the effects on the kidney. Material and Methods The study included 21 adolescent (average age 6 weeks) Sprague-Dawley male rats weighing between 240-290g divided at random into 3 groups. Group-1: Control group (n=6): underwent no procedures. Group-2: Sham group (n=6): underwent the same procedures as the experimental group without ureter and psoas muscle dissection. Group-3: Group with induced partial unilateral ureteral obstruction (n=9). All rats were sacrificed after 12 weeks. Superoxide dismutase enzyme activity and nitrite and nitrate salt levels were measured in renal tissue. Plasma nitrite-nitrate and ADMA levels were examined. Results In the experimental group histopathological changes observed included renal pelvis dilatation, flattened papillae, sclerotic glomerulus and fibrosis. In the experimental group tissue SOD and blood ADMA levels were higher than the control and sham groups (p |
| Databáze: | OpenAIRE |
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