Genetic Framework of Cyclin-Dependent Kinase Function in Arabidopsis
| Autor: | Xin’Ai Zhao, Arp Schnittger, Hirofumi Harashima, Daniel Bouyer, Freya De Winter, Annika K. Weimer, Nico Dissmeyer, Fang Yang, Moritz K. Nowack |
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| Přispěvatelé: | Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire de physique des interfaces et des couches minces [Palaiseau] (LPICM), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X), CNRS Délégation Régionale Paris B (CNRS DR2), Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris |
| Rok vydání: | 2012 |
| Předmět: |
0106 biological sciences
Mutant Arabidopsis Mitosis [SDV.BC]Life Sciences [q-bio]/Cellular Biology medicine.disease_cause Plant Roots 01 natural sciences General Biochemistry Genetics and Molecular Biology S Phase [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction Evolution Molecular [SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics 03 medical and health sciences Cyclin-dependent kinase CDC2-CDC28 Kinases medicine [SDV.BV]Life Sciences [q-bio]/Vegetal Biology [SDV.BDD]Life Sciences [q-bio]/Development Biology Molecular Biology ComputingMilieux_MISCELLANEOUS 030304 developmental biology Genetics 0303 health sciences Cyclin-dependent kinase 1 Mutation biology Arabidopsis Proteins Kinase Retinoblastoma protein [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology Cell Biology biology.organism_classification Cyclin-Dependent Kinases Cell biology Microscopy Electron Scanning biology.protein biological phenomena cell phenomena and immunity Plant Shoots 010606 plant biology & botany Developmental Biology |
| Zdroj: | Developmental Cell Developmental Cell, Elsevier, 2012, 22 (5), pp.1030-40 Developmental Cell, Elsevier, 2012, 22 (5), pp.1030-1040. ⟨10.1016/j.devcel.2012.02.015⟩ |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2012.02.015 |
| Popis: | SummaryCyclin-dependent kinases (CDKs) are at the heart of eukaryotic cell-cycle control. The yeast Cdc2/CDC28 PSTAIRE kinase and its orthologs such as the mammalian Cdk1 have been found to be indispensable for cell-cycle progression in all eukaryotes investigated so far. CDKA;1 is the only PSTAIRE kinase in the flowering plant Arabidopsis and can rescue Cdc2/CDC28 mutants. Here, we show that cdka;1 null mutants are viable but display specific cell-cycle and developmental defects, e.g., in S phase entry and stem cell maintenance. We unravel that the crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and that codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants. Our work further revealed a basic cell-cycle control system relying on two plant-specific B1-type CDKs, and the triple cdk mutants displayed an early germline arrest. Taken together, our data indicate divergent functional differentiation of Cdc2-type kinases during eukaryote evolution. |
| Databáze: | OpenAIRE |
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