A new in vivo Raman probe for enhanced applicability to the body
| Autor: | Paul D. A. Pudney, Gerwin J. Puppels, Martin J. G. van der Wolf, Chris Marriot, Scott Singleton, Jean-Philippe Gorce, Eleanor Y. M. Bonnist, Peter J. Caspers |
|---|---|
| Přispěvatelé: | Dermatology |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Spectrum Analysis Raman Catechin law.invention symbols.namesake Young Adult Forearm Optical coherence tomography law In vivo medicine Humans Optical flat Instrumentation Spectroscopy Scalp integumentary system Spectrometer medicine.diagnostic_test Chemistry Mouth Mucosa Equipment Design Middle Aged Lipids body regions Axilla medicine.anatomical_structure Organ Specificity symbols Female Epidermis Raman spectroscopy Biomedical engineering |
| Zdroj: | Applied Spectroscopy, 66(8), 882-891. SAGE Publishing |
| ISSN: | 1943-3530 0003-7028 |
| Popis: | This paper describes a new in vivo Raman probe that allows investigation of areas of the body that are otherwise difficult to access. It is coupled to a previously described commercially available in vivo Raman spectrometer that samples the skin through an optical flat. In the work presented here, the laser light emerges from a smaller pen-shaped probe. It thus works on the same principles as the original spectrometer, while its relative performance in terms of signal-to-noise ratio of the spectra and obtained spatial resolution is only slightly diminished. It allows the window to be placed against the subject in more curved and recessed areas of subject's body and also for them to be more comfortable while the measurements take place. Results from three areas of the body that have previously been very difficult to study are described, the mouth, axilla, and scalp. Results from the scalp and axilla strata cornea (SC) show significant differences from the “normal” SC of the volar forearm. For instance, the scalp is observed to have lower amounts of natural moisturizing factors (NMF) compared to the volar forearm within the same subjects. Also for both the axilla and scalp the lipids show a change in order as compared to the lipids in the volar forearm and also differences from each other. The potential significance of these observations is discussed. Further, we show how we can probe the mouth, in this case observing the presence of the astringent tea polyphenol epigallocatechin gallate within the oral mucosa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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