Cerebral metabolism in hepatic insufficiency
| Autor: | Wilfred R. Ehrmantraut, Joseph F. Fazekas, Ralph W. Alman, Howard E. Ticktin |
|---|---|
| Rok vydání: | 1956 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty business.industry Liver Diseases Apparent oxygen utilisation Brain General Medicine Cerebral metabolism Enzyme Endocrinology Metabolic Diseases chemistry Cerebral hemodynamics Internal medicine medicine Hepatic Insufficiency Humans Blood ammonia business |
| Zdroj: | The American Journal of Medicine. 21:843-849 |
| ISSN: | 0002-9343 |
| Popis: | S TUDIES dealing with neurologic disturbances associated with hepatic insufficiency have been confined chiefly to attempts at identifying the neurotoxic substance or substances responsible for the condition. For the most part, attention has been directed to the concentration of ammonia and other nitrogenous or sulfur-containing compounds in the arteriallP3 and cerebral venous blood.4 It is believed that these substances may alter the activity of certain enzyme complexes concerned with intermediate cerebral metabolism.4 In the present study, cerebral hemodynamics and oxygen utilization of patients with varying degrees of neurologic dysfunction associated with hepatic insufficiency were investigated to determine whether or not changes in the functions mentioned could be correlated with alterations in blood ammonia and pyruvate levels or with electroencephalographic activity. |
| Databáze: | OpenAIRE |
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