Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources
| Autor: | Abdul Jalil Shah, Mubashir Hussain Masoodi, Reyaz Hassan Mir, Roohi Mohi-ud-din, Faheem Hyder Pottoo, Zulfiqar Ali Bhat |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
media_common.quotation_subject Population Serotonergic Norepinephrine Medicine Humans Pharmacology (medical) Available drugs education Cyclic hydrocarbon Depression (differential diagnoses) media_common Pharmacology education.field_of_study Biological Products Depressive Disorder business.industry Depression Dopaminergic General Medicine Antidepressive Agents Psychiatry and Mental health Monoamine neurotransmitter Neurology Neurology (clinical) business Neuroscience Phytotherapy |
| Zdroj: | Current neuropharmacology. 19(11) |
| ISSN: | 1875-6190 |
| Popis: | Depression, a well-known mental disorder, has global prevalence, affecting nearly 17% of the population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main sources for new drug candidates of depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic systems, and elevation of BDNF levels. The focus of this article is to review the role of signalling molecules in depression and highlight the use of plant-derived natural compounds to counter CNS depression. |
| Databáze: | OpenAIRE |
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