Reversible RNA modifications in meiosis and pluripotency
| Autor: | Adam Filipczyk, Arne Klungland, Peter Fedorcsak, Gareth D. Greggains, John Arne Dahl |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pluripotent Stem Cells Messenger RNA Rex1 RNA Cell Biology Methylation Biology Biochemistry Embryonic stem cell Cell biology Epigenesis Genetic 03 medical and health sciences Meiosis 030104 developmental biology 0302 clinical medicine Animals Humans Epigenetics Induced pluripotent stem cell Molecular Biology 030217 neurology & neurosurgery Biotechnology Epigenesis |
| Zdroj: | Nature methods. 14(1) |
| ISSN: | 1548-7105 |
| Popis: | Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, readers and erasers has recently advanced tremendously. Here we focus on the roles of the dynamic methylation and demethylation of internal adenosines in mRNA in germ cells and pluripotent stem cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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