Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients
| Autor: | Pedro López-Muñoz, Amparo Alba, Belén Beltrán, Pilar Nos, Esteban Sáez-González, Marisa Iborra |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Crohn’s disease Exacerbation faecal calprotectin vitamin D Gastroenterology Inflammatory bowel disease Severity of Illness Index 0302 clinical medicine Crohn Disease Medicine Longitudinal Studies Crohn's disease Nutrition and Dietetics biology Middle Aged Ulcerative colitis Hospitalization Intestines 030211 gastroenterology & hepatology Female Inflammation Mediators lcsh:Nutrition. Foods and food supply Adult medicine.medical_specialty lcsh:TX341-641 vitamin D deficiency Article C-reactive protein 03 medical and health sciences Internal medicine Vitamin D and neurology Humans Calcifediol Retrospective Studies ulcerative colitis Inflammation business.industry Fibrinogen medicine.disease Inflammatory Bowel Diseases Vitamin D Deficiency Faecal calprotectin 030104 developmental biology Multivariate Analysis biology.protein Colitis Ulcerative business Leukocyte L1 Antigen Complex Biomarkers Food Science |
| Zdroj: | Nutrients r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Volume 11 Issue 5 Nutrients, Vol 11, Iss 5, p 1059 (2019) |
| ISSN: | 2072-6643 |
| Popis: | Vitamin D has recently been discovered to be a potential immune modulator. Low serum vitamin D levels have been associated with risk of relapse and exacerbation of clinical outcomes in Crohn&rsquo s disease (CD) and ulcerative colitis (UC). A retrospective, longitudinal study was conducted to determine the association between vitamin D levels and inflammatory markers and clinical disease activity in inflammatory bowel disease (IBD). In addition, circulating 25(OH)D3 progression was evaluated according to vitamin D supplementation. Participants were separated into three groups according to their vitamin D level: severe deficiency (SD), moderate deficiency (MD) and sufficiency (S). Serum 25(OH)D3 was inversely correlated with faecal calprotectin (FC) for CD and UC but was only correlated with C-reactive protein (CRP) for UC patients. In the multivariate analysis of FC, CRP and fibrinogen (FBG), we predicted the presence of a patient in the SD group with 80% accuracy. A deficiency of 25(OH)D3 was associated with increased hospitalisations, flare-ups, the use of steroids and escalating treatment. Supplemental doses of vitamin D were likely to be insufficient to reach adequate serum levels of 25(OH)D3. Vitamin D intervention studies are warranted to determine whether giving higher doses of vitamin D in IBD might reduce intestinal inflammation or disease activity. |
| Databáze: | OpenAIRE |
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