Injectable Hydrogels Based on Pluronic/Water Systems Filled with Alginate Microparticles for Biomedical Applications
| Autor: | Henrique Carrêlo, João Borges, D J Ramos, Nuria Calero, José Luis Alonso Santos, Maria Teresa Cidade |
|---|---|
| Přispěvatelé: | Universidad de Sevilla. Departamento de Ingeniería Química |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pluronic/water systems
Composite number Injectable hydrogels injectable gels 02 engineering and technology 010402 general chemistry lcsh:Technology 01 natural sciences composites Article chemistry.chemical_compound Tissue engineering Hydrogel composite General Materials Science lcsh:Microscopy lcsh:QC120-168.85 lcsh:QH201-278.5 lcsh:T Poloxamer 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Chemical engineering lcsh:TA1-2040 Drug delivery Drug release lcsh:Descriptive and experimental mechanics alginate microparticles rheology lcsh:Electrical engineering. Electronics. Nuclear engineering lcsh:Engineering (General). Civil engineering (General) 0210 nano-technology lcsh:TK1-9971 Methylene blue dual cargo delivery systems |
| Zdroj: | Materials Volume 12 Issue 7 Materials, Vol 12, Iss 7, p 1083 (2019) idUS. Depósito de Investigación de la Universidad de Sevilla instname |
| ISSN: | 1996-1944 |
| DOI: | 10.3390/ma12071083 |
| Popis: | A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt%) and appropriate alginate microparticles contents (5 and 10 wt%) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering. |
| Databáze: | OpenAIRE |
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