Eucalyptol, an essential oil, reduces contractile activity in rat cardiac muscle

Autor: M C M S Soares, Ivanita Stefanon, C E N Damiani, Cleci Menezes Moreira, Dalton Valentim Vassallo
Rok vydání: 2005
Předmět:
Inotrope
Male
Vascular smooth muscle
Physiology
Drug Evaluation
Preclinical
Isometric exercise
Calcium channel blocker
Biochemistry
chemistry.chemical_compound
General Pharmacology
Toxicology and Pharmaceutics
lcsh:QH301-705.5
lcsh:R5-920
Chemistry
General Neuroscience
Skeletal Muscle Myosins
Cardiac muscle
General Medicine
Papillary Muscles
Sarcoplasmic Reticulum
medicine.anatomical_structure
Anesthesia
Myocardial contractility
lcsh:Medicine (General)
medicine.medical_specialty
medicine.drug_class
Immunology
Biophysics
chemistry.chemical_element
Calcium
Contractility
Internal medicine
Isometric Contraction
medicine
Oils
Volatile
Animals
Rats
Wistar
Tetanic tension
Eucalyptol
Dose-Response Relationship
Drug
Cálcio
Isoproterenol
Cell Biology
Cyclohexanols
Myocardial Contraction
Rats
Endocrinology
Eucaliptol
lcsh:Biology (General)
Monoterpenes
Zdroj: Brazilian Journal of Medical and Biological Research v.38 n.3 2005
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 38, Iss 3, Pp 453-461 (2005)
Brazilian Journal of Medical and Biological Research, Volume: 38, Issue: 3, Pages: 453-461, Published: MAR 2005
Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)
Universidade Federal do Espírito Santo (UFES)
instacron:UFES
ISSN: 0100-879X
Popis: Submitted by Morgana Andrade (morgana.andrade@ufes.br) on 2011-02-07T19:35:58Z No. of bitstreams: 2 5472.pdf: 588163 bytes, checksum: 353d3253838bd277495dfbb4a49aa732 (MD5) license_rdf: 21504 bytes, checksum: cfe16b28a928230b24b965de15e8a5ff (MD5) Approved for entry into archive by Patricia Barros(patricia.barros@ufes.br) on 2011-03-04T18:41:17Z (GMT) No. of bitstreams: 2 5472.pdf: 588163 bytes, checksum: 353d3253838bd277495dfbb4a49aa732 (MD5) license_rdf: 21504 bytes, checksum: cfe16b28a928230b24b965de15e8a5ff (MD5) Made available in DSpace on 2011-03-04T18:41:17Z (GMT). No. of bitstreams: 2 5472.pdf: 588163 bytes, checksum: 353d3253838bd277495dfbb4a49aa732 (MD5) license_rdf: 21504 bytes, checksum: cfe16b28a928230b24b965de15e8a5ff (MD5) Previous issue date: 2005-03 Eucalyptol is an essential oil that relaxes bronchial and vascular smooth muscle although its direct actions on isolated myocardium have not been reported. We investigated a putative negative inotropic effect of the oil on left ventricular papillary muscles from male Wistar rats weighing 250 to 300 g, as well as its effects on isometric force, rate of force development, time parameters, post-rest potentiation, positive inotropic interventions produced by Ca2+ and isoproterenol, and on tetanic tension. The effects of 0.3 mM eucalyptol on myosin ATPase activity were also investigated. Eucalyptol (0.003 to 0.3 mM) reduced isometric tension, the rate of force development and time parameters. The oil reduced the force developed by steady-state contractions (50% at 0.3 mM) but did not alter sarcoplasmic reticulum function or post-rest contractions and produced a progressive increase in relative potentiation. Increased extracellular Ca2+ concentration (0.62 to 5 mM) and isoproterenol (20 nM) administration counteracted the negative inotropic effects of the oil. The activity of the contractile machinery evaluated by tetanic force development was reduced by 30 to 50% but myosin ATPase activity was not affected by eucalyptol (0.3 mM), supporting the idea of a reduction of sarcolemmal Ca2+ influx. The present results suggest that eucalyptol depresses force development, probably acting as a calcium channel blocker.
Databáze: OpenAIRE
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