Thioridazine enantiomers in human tissues
| Autor: | James C. Valentour, Saeed A. Jortani, Alphonse Poklis |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Liver chemistry Tissue concentrations Thioridazine Pharmacology High-performance liquid chromatography Pathology and Forensic Medicine Fluoxetine medicine Humans Chromatography High Pressure Liquid Brain Chemistry Chromatography Chemistry Biological materials Body Fluids Suicide Liver Postmortem Changes Female Stereoselectivity Enantiomer Law Quantitative analysis (chemistry) medicine.drug |
| Zdroj: | Forensic Science International. 64:165-170 |
| ISSN: | 0379-0738 |
| DOI: | 10.1016/0379-0738(94)90227-5 |
| Popis: | Enantiomers of thioridazine (TRZ) were determined in postmortem tissues obtained from a patient on chronic TRZ therapy by sequential achiral and chiral high pressure liquid chromatography. Tissue concentrations of (+)-TRZ found in liver, brain, bile and blood were: 6.46, 0.40, 0.48 and 0.07 mg/l or mg/kg, respectively. Concentrations of (-)-TRZ in liver, brain, bile and blood were: 12.2, 0.81, 1.07 and 0.20 mg/l or mg/kg, respectively. These data demonstrate the stereoselective disposition of TRZ in human tissues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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