Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study
| Autor: | Kirsti Ytrehus, Svetlana N. Zykova, Marit Dahl Solbu, Hilde-Merete Storhaug, Bjørn Odvar Eriksen, Trond Jenssen, Jon Viljar Norvik |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male Time Factors Blood Pressure 030204 cardiovascular system & hematology Overweight Body Mass Index 0302 clinical medicine Risk Factors Odds Ratio Longitudinal Studies Prospective Studies 030212 general & internal medicine Prospective cohort study Norway VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 Cohort Middle Aged Metabolic syndrome Up-Regulation Prospective Hypertension Female medicine.symptom Cardiology and Cardiovascular Medicine Research Article medicine.medical_specialty Hyperuricemia Risk Assessment 03 medical and health sciences Insulin resistance Internal medicine medicine Humans Obesity National Cholesterol Education Program Aged Chi-Square Distribution business.industry Odds ratio medicine.disease Cardiovascular risk Logistic Models Endocrinology Hyperglycemia Multivariate Analysis Linear Models Longitudinal business Body mass index Uric acid Biomarkers |
| Zdroj: | BMC Cardiovascular Disorders |
| Popis: | Published version. Source at http://dx.doi.org/10.1186/s12872-016-0265-8 Background: Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS). In a prospective cohort study, we assessed whether baseline and longitudinal change in UA were risk factors for development of MetS and its individual components. Methods: We included 3087 women and 2996 men who had UA measured in the population based Tromsø Study 1994–95. The participants were stratified according to body mass index (BMI). Endpoints were MetS and each component of the syndrome after 7 years, according to the revised National Cholesterol Education Program’s Adult Treatment Panel III (NCEP-ATP III) definition. Results: Multiple logistic regression analyses showed that higher baseline UA was associated with higher odds of developing elevated blood pressure in overweight subjects (BMI ≥ 25 kg/m2, odds ratio [OR] per 59 μmol/L UA increase 1.44, 95 % confidence interval [CI] = 1.17–1.77, P = 0.001), but not in normal-weight subjects (BMI < 25 kg/m2, P for interaction = 0.04). Overweight also modified the association between baseline UA and the development of elevated fasting glucose (P for interaction = 0.01). UA was a predictor of MetS in all subjects (OR per 59 μmol/L UA increase 1.29, 95 % CI 1.18–1.41, P < 0.001). Furthermore, longitudinal UA change was independently associated with the development of MetS in all subjects (OR per 59 μmol/L UA increase over 7 years 1.28, 95 % CI 1.16–1.42, P < 0.001). Conclusion: Increased levels of baseline UA independently predicted development of elevated blood pressure and higher fasting glycemia in the overweight, but not the normal-weight subjects. Baseline UA and longitudinal increase in UA over 7 years was associated with the development of MetS in all subjects. Whether increased UA should be treated differently in normal-weight and overweight persons needs further study. |
| Databáze: | OpenAIRE |
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