Systematic Analysis of microRNA Biomarkers for Diagnosis, Prognosis, and Therapy in Patients With Clear Cell Renal Cell Carcinoma
| Autor: | Zhongyi Yan, Longxiang Xie, Lu Zhang, Xiangqian Guo, Yali Han, Mengru Li, Guosen Zhang, Fangmei Nan, Guiyun Cheng, Xiaoyu Ma, Huimin Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research diagnosis molecular targeted therapy clear cell renal cell carcinoma medicine.disease_cause lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine microRNA medicine KEGG Gene miRNA Kidney Cell growth business.industry biomarkers Cancer lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease circulating miRNA Clear cell renal cell carcinoma 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Systematic Review prognosis business Carcinogenesis |
| Zdroj: | Frontiers in Oncology, Vol 10 (2020) Frontiers in Oncology |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2020.543817 |
| Popis: | The ever-increasing morbidity and mortality of clear cell renal cell carcinoma (ccRCC) urgently demands updated biomarkers. MicroRNAs (miRNAs) are involved in diverse biological processes such as cell proliferation, differentiation, apoptosis by regulating their target genes’ expression. In kidney cancers, miRNAs have been reported to be involved in tumorigenesis and to be the diagnostic, prognostic, and therapeutic response biomarkers. Here, we performed a systematic analysis for ccRCC-related miRNAs as biomarkers by searching keywords in the NCBI PubMed database and found 118 miRNAs as diagnostic biomarkers, 28 miRNAs as prognostic biomarkers, and 80 miRNAs as therapeutic biomarkers in ccRCC. miRNA-21, miRNA-155, miRNA-141, miRNA-126, and miRNA-221, as significantly differentially expressed miRNAs between cancer and normal tissues, play extensive roles in the cell proliferation, differentiation, apoptosis of ccRCC. GO and KEGG enrichment analysis of these miRNAs’ target genes through Metascape showed these target genes are enriched in Protein Domain Specific Binding (GO:0019904). In this paper, we identified highly specific miRNAs in the pathogenesis of ccRCC and explored their potential applications for diagnosis, prognosis, and treatment of ccRCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|