Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study

Autor: Buetti, Niccolò, Tabah, Alexis, Loiodice, Ambre, Ruckly, Stéphane, Aslan, Abdullah Tarik, Montrucchio, Giorgia, Cortegiani, Andrea, Saltoglu, Nese, Kayaaslan, Bircan, Aksoy, Firdevs, Murat, Akova, Akdoğan, Özlem, Saracoglu, Kemal Tolga, Erdogan, Cem, Leone, Marc, Ferrer, Ricard, Paiva, José-Artur, Hayashi, Yoshiro, Ramanan, Mahesh, Conway Morris, Andrew, Barbier, François, Timsit, Jean-François, Lipman, Jeffrey, Litton, Edward, Palermo, Anna Maria, Yap, Timothy, Eroglu, Ege, Hosokawa, Koji, Yoshida, Hideki, Fujitani, Shigeki, Zand, Farid, Mahmoodpoor, Ata, Tabatabaei, Seyed Mohammad Nasirodin, Elrabi, Omar, Almekhlafi, Ghaleb A, Vidal, Gabriela, Aparicio, Marta, Alonzo, Irene, Namendys-Silva, Silvio A, Hermosillo, Mariana, Castillo, Roberto Alejandro, De Bus, Liesbet, De Waele, Jan, Hollevoet, Isabelle, De Schryver, Nicolas, Serck, Nicolas, Kovacevic, Pedja, Zlojutro, Biljana, Ruppe, Etienne, Montravers, Philippe, Dulac, Thierry, Castanera, Jérémy, Massri, Alexandre, Guesdon, Charlotte, Garcon, Pierre, Duprey, Matthieu, Philippart, François, Tran, Marc, Bruel, Cédric, Kalfon, Pierre, Badre, Gaëtan, Demeret, Sophie, Le Guennec, Loïc, Bassetti, Matteo, Giacobbe, Daniele, Sales, Gabriele, Daroui, Ivan, Lodi, Giovanni, Ippolito, Mariachiara, Bellina, Davide, Di Guardo, Andrea, Rocco, Monica, Fiorelli, Silvia, Mikstacki, Adam, Peichota, Mariusz, Pietraszek-Grzywaczewska, Iwona, Póvoa, Pedro, Krystopchuk, Andriy, Teresa, Ana, De Figueiredo, António Manuel Pereira, Botelho, Isabel, Costa, Vasco, Cunha, Rui Pedro, Gritsan, Alexey, Belskiy, Vladislav, Furman, Mikhail, Martinez, Maria, Casares, Vanessa, Arnillas, Maria Pilar Gracia, Bermudez, Rosana Munoz, Ubeda, Alejandro, Salgado, Maria, Maseda, Emilio, De La Rica, Alejandro Suarez, Blasco-Navalpotro, Miguel Angel, Gallego, Alberto Orejas, Prazak, Josef, Pagani, JL, Abed-Maillard, S, Iskit, Arzu Topeli, Mehtap, Selcuk, Ceyhun, Solakoğlu, Kalem, Ayşe Kaya, Kurt, Ibrahim, Telli, Murat, Ozturk, Barcin, Baykam, Nurcan, Karaali, Ridvan, Koksal, Iftihar, Bilir, Yeliz, Guzeldag, Seda, Ersoz, Gulden, Evik, Guliz, Bayindir, Yasar, Ersoy, Yasemin, Ercole, Ari, Raj, Ashok, Zormpa, Artemis, Tinaslanidis, George, Khade, Reena, Roshdy, Ashraf, Kannan, Santhana, Antrolikar, Supriya, Marsden, Nicholas, Attwood, Ben, Patel, Jamie, Gurjar, Mohan, Dsilva, Carol, Chandran, Jagadish, Sanousi, Bashir El, Saidahmed, Elfayadh, Hamid, Hytham KS
Přispěvatelé: Buetti, Niccolò, Tabah, Alexi, Loiodice, Ambre, Ruckly, Stéphane, Aslan, Abdullah Tarik, Montrucchio, Giorgia, Cortegiani, Andrea, Saltoglu, Nese, Kayaaslan, Bircan, Aksoy, Firdev, Murat, Akova, Akdoğan, Özlem, Saracoglu, Kemal Tolga, Erdogan, Cem, Leone, Marc, Ferrer, Ricard, Paiva, José-Artur, Hayashi, Yoshiro, Ramanan, Mahesh, Conway Morris, Andrew, Barbier, Françoi, Timsit, Jean-François, Conway Morris, Andrew [0000-0002-3211-3216], Apollo - University of Cambridge Repository, Institut Català de la Salut, [Buetti N] Infection Control Program and WHO Collaborating Centre on Patient Safety, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. INSERM, IAME, Université Paris-Cité, Paris, France. [Tabah A] Intensive Care Unit, Redclife Hospital, Metro North Hospital and Health Services, Brisbane, QLD, Australia. Queensland University of Technology, Brisbane, QLD, Australia. Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia. [Loiodice A, Ruckly S] ICURESEARCH, Fonaine, France. [Aslan AT] Department of Internal Medicine, Hacettepe University, Sihhiye, Ankara, Turkey. [Montrucchio G] Department of Surgical Sciences, University of Turin, Turin, Italy. Department of Anaesthesia, Critical Care and Emergency, Città Della Salute e Della Scienza Hospital, Turin, Italy. [Ferrer R] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Xoc, Disfunció Orgànica i Ressuscitació, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Timsit, Jean-Françoi, Lipman, Jeffrey, Litton, Edward, Palermo, Anna Maria, Yap, Timothy, Eroglu, Ege, Hosokawa, Koji, Yoshida, Hideki, Fujitani, Shigeki, Zand, Farid, Mahmoodpoor, Ata, Tabatabaei, Seyed Mohammad Nasirodin, Elrabi, Omar, Almekhlafi, Ghaleb A., Vidal, Gabriela, Aparicio, Marta, Alonzo, Irene, Namendys-Silva, Silvio A., Hermosillo, Mariana, Castillo, Roberto Alejandro, De Bus, Liesbet, De Waele, Jan, Hollevoet, Isabelle, De Schryver, Nicola, Serck, Nicola, Kovacevic, Pedja, Zlojutro, Biljana, Ruppe, Etienne, Montravers, Philippe, Dulac, Thierry, Castanera, Jérémy, Massri, Alexandre, Guesdon, Charlotte, Garcon, Pierre, Duprey, Matthieu, Philippart, Françoi, Tran, Marc, Bruel, Cédric, Kalfon, Pierre, Badre, Gaëtan, Demeret, Sophie, Le Guennec, Loïc, Bassetti, Matteo, Giacobbe, Daniele, Sales, Gabriele, Daroui, Ivan, Lodi, Giovanni, Ippolito, Mariachiara, Bellina, Davide, Di Guardo, Andrea, Rocco, Monica, Fiorelli, Silvia, Mikstacki, Adam, Peichota, Mariusz, Pietraszek-Grzywaczewska, Iwona, Póvoa, Pedro, Krystopchuk, Andriy, Teresa, Ana, de Figueiredo, António Manuel Pereira, Botelho, Isabel, Costa, Vasco, Cunha, Rui Pedro, Gritsan, Alexey, Belskiy, Vladislav, Furman, Mikhail, Martinez, Maria, Casares, Vanessa, Arnillas, Maria Pilar Gracia, Bermudez, Rosana Munoz, Ubeda, Alejandro, Salgado, Maria, Maseda, Emilio, De La Rica, Alejandro Suarez, Blasco-Navalpotro, Miguel Angel, Gallego, Alberto Oreja, Prazak, Josef, Pagani, J. L., Abed-Maillard, S., Iskit, Arzu Topeli, Mehtap, Selcuk, Ceyhun, Solakoğlu, Kalem, Ayşe Kaya, Kurt, Ibrahim, Telli, Murat, Ozturk, Barcin, Baykam, Nurcan, Karaali, Ridvan, Koksal, Iftihar, Bilir, Yeliz, Guzeldag, Seda, Ersoz, Gulden, Evik, Guliz, Bayindir, Yasar, Ersoy, Yasemin, Ercole, Ari, Raj, Ashok, Zormpa, Artemi, Tinaslanidis, George, Khade, Reena, Roshdy, Ashraf, Kannan, Santhana, Antrolikar, Supriya, Marsden, Nichola, Attwood, Ben, Patel, Jamie, Gurjar, Mohan, Dsilva, Carol, Chandran, Jagadish, Sanousi, Bashir El, Saidahmed, Elfayadh, Hamid, Hytham K. S.
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Male
bloodstream infections
Other subheadings::Other subheadings::/epidemiology [Other subheadings]
Critical Illness
COVID-19 (Malaltia) - Epidemiologia
RESISTANT ENTEROCOCCI
Bacteremia
Bloodstream infection
Critical Care and Intensive Care Medicine
Pathological Conditions
Signs and Symptoms::Pathologic Processes::Disease Attributes::Critical Illness [DISEASES]
Cohort Studies
afecciones patológicas
signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedad crítica [ENFERMEDADES]
Sepsis
virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES]
Medicine and Health Sciences
Humans
NCT03937245
Unitats de cures intensives
Aged
Cross Infection
Malalties bacterianes
infecciones bacterianas y micosis::infección::infección hospitalaria [ENFERMEDADES]
Research
Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores]
COVID-19
Enterococcus
ICU-acquired
Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES]
Bacterial Infections and Mycoses::Infection::Cross Infection [DISEASES]
Intensive Care Units
NCT
ICU
RNA
Zdroj: CRITICAL CARE
Scientia
ISSN: 1364-8535
1466-609X
Popis: Funder: European society of Intensive Care Medicine
Funder: European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Funder: Norva Dahlia foundation and the Redcliffe Hospital Private Practice Trust Fund
Background The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients’ characteristics, source of infection and microorganism distribution. We studied the association between COVID-19 status and mortality using multivariable fragility Cox models. Results A total of 53 centers from 19 countries over the 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) were treated for a HABSI. Included patients comprised 252 (30.4%) COVID-19 and 577 (69.6%) non-COVID-19 patients. The time interval between hospital admission and HABSI was similar between both groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) and primary HABSI (25.4% vs. 17.2%, p = 0.006) were more frequent in COVID-19 patients. COVID-19 patients had more often enterococcal (20.5% vs. 9%) and Acinetobacter spp. (18.8% vs. 13.6%) HABSIs. Bacteremic COVID-19 patients had an increased mortality hazard ratio (HR) versus non-COVID-19 patients (HR 1.91, 95% CI 1.49–2.45). Conclusions We showed that the epidemiology of HABSI differed between COVID-19 and non-COVID-19 patients. Enterococcal HABSI predominated in COVID-19 patients. COVID-19 patients with HABSI had elevated risk of mortality. Trial registration ClinicalTrials.org number NCT03937245. Registered 3 May 2019.
Databáze: OpenAIRE
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