Mapping the relationship between clinical and quality-of-life outcomes in patients with ankylosing spondylitis
| Autor: | Andrea Smrzova, David Suchy, T. Mlcoch, Liliana Šedová, Monika Urbanova, Karel Pavelka, Tomas Dolezal, J. Stolfa, Jitka Jircikova |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Severity of Illness Index 03 medical and health sciences Sex Factors 0302 clinical medicine Quality of life Linear regression medicine Humans Spondylitis Ankylosing Pharmacology (medical) Longitudinal Studies Prospective Studies 030212 general & internal medicine business.industry 030503 health policy & services Health Policy Regression analysis General Medicine Fixed effects model Middle Aged Models Theoretical Random effects model Regression Linear Models Quality of Life Physical therapy Female Outcomes research 0305 other medical science BASFI business Follow-Up Studies |
| Zdroj: | Expert Review of Pharmacoeconomics & Outcomes Research. 17:203-211 |
| ISSN: | 1744-8379 1473-7167 |
| DOI: | 10.1080/14737167.2016.1200468 |
| Popis: | To map health-related quality of life (Qol) with clinical parameters BASFI and ASDAS-CRP measure, and other covariates.Our prospective multicenter non-interventional observation study of ankylosing spondylitis (AS) collected data about QoL and clinical outcomes on the initial and four subsequent visits. We employed simple linear regression analysis of a cross-sectional dataset, and fixed effect, random effect and pooled linear regression of a longitudinal dataset.We showed that BASFI and ASDAS-CRP are very strong, robust predictors of EQ-5D utilities in all regression specifications together with sex (female), invalidity, and activity impairment. Additionally, the longitudinal regression analysis showed that a fixed effect model may be a viable alternative to the most commonly used random effect model or pooled linear regression due to the nature of our dataset.This is one of the first studies using a fixed effect model in longitudinal patient-level data, although, this method has been widely used in economics. |
| Databáze: | OpenAIRE |
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