School based screening for hypothyroidism in Down's syndrome by dried blood spot TSH measurement
| Autor: | Malcolm Donaldson, J M Mackenzie, S E Noble, R W A Girdwood, C A Findlay, J Redfern, Kath Leyland, C E Clark |
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| Rok vydání: | 2000 |
| Předmět: |
Male
endocrine system Pediatrics medicine.medical_specialty Down syndrome endocrine system diseases Adolescent Population Child Health Services Thyrotropin Thyroiditis Thyroid-stimulating hormone Hypothyroidism Internal medicine medicine Humans Mass Screening education Child Letters to the Editor Mass screening School Health Services education.field_of_study business.industry Thyroid disease medicine.disease United Kingdom Dried blood spot Endocrinology Community Child Health Public Health and Epidemiology El Niño Child Preschool Pediatrics Perinatology and Child Health Feasibility Studies Female Down Syndrome business hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | Archives of disease in childhood. 82(1) |
| ISSN: | 1468-2044 |
| Popis: | OBJECTIVE To determine the feasibility of annual hypothyroid screening of children with Down9s syndrome by measuring thyroid stimulating hormone (TSH) on dried blood spots at school, and to describe the outcome in positive children. DESIGN Establishment of a register of school children with Down9s syndrome, and procedures for obtaining permission from parents, annual capillary blood samples, TSH measurement, and clinical assessment of children with TSH values > 10 mU/litre. SUBJECTS All school age children with Down9s syndrome within Lanarkshire and Glasgow Health Boards during 1996–7 and 1997–8. RESULTS 200 of 214 school children with Down9s syndrome were screened. Four of the unscreened children were receiving thyroxine treatment, and only 5 remained unscreened by default. 15 of the 200 children had capillary TSH > 10 mU/litre, and all but 1 had evidence of Hashimoto9s thyroiditis. Seven of the 15 children started thyroxine treatment immediately, 6 with a pronounced rise in venous TSH and subnormal free thyroxine (fT4), and one with mildly raised TSH and normal fT4 but symptoms suggesting hypothyroidism. Eight children with mildly raised venous TSH and normal fT4 were left untreated; 1 year after testing positive, fT4 remained > 9 pmol/litre in all cases, but 4 children were started on thyroxine because of a rise in TSH. TSH fell in 3 of the 4 remaining children and there was a marginal rise in 1; all remain untreated. The prevalence of thyroid disease in this population is ⩾ 8.9%. CONCLUSION Dried blood spot TSH measurement is effective for detecting hypothyroidism in Down9s syndrome and capillary sampling is easily performed at school. The existing programme could be extended to the whole of Scotland within a few years. |
| Databáze: | OpenAIRE |
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