Histologic evaluation of preventive measures for scald injury on the peritoneo-serosal surface due to intraoperative hyperthermic chemoperfusion for patients with gastric cancer and peritoneal metastasis
| Autor: | E. Izawa, T. Toyosawa, T. Numai, Makoto Takahashi, F. Kondoh, T. Mutou, Shigeru Fujimoto, Kokuriki Kobayashi, H. Ohkubo |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Hyperthermia Cancer Research Peritoneal metastasis medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Physiology Antineoplastic Agents Gastroenterology chemistry.chemical_compound Drug Therapy Stomach Neoplasms Physiology (medical) Internal medicine medicine Humans Neoplasm Metastasis Cimetidine Histocytochemistry business.industry Stomach Temperature Antagonist Cancer Histology Hyperthermia Induced Middle Aged medicine.disease Surgery Perfusion Jejunum medicine.anatomical_structure Histamine H2 Antagonists chemistry Female Peritoneum Burns business Histamine medicine.drug |
| Zdroj: | International Journal of Hyperthermia. 14:75-83 |
| ISSN: | 1464-5157 0265-6736 |
| DOI: | 10.3109/02656739809018216 |
| Popis: | To histologically assess the preventive efficacy of cimetidine against scald injury on the peritoneo-serosal surface during intraperitoneal hyperthermic chemoperfusion (IHCP) for advanced gastric cancer, a randomized histologic study using cimetidine, a histamine H2-receptor antagonist, was performed for 20 patients with advanced or recurrent gastric cancer and peritoneal metastasis. Cimetidine 50 mg/kg was administered intravenously to 10 patients just prior to the IHCP (cimetidine group), and the remaining 10 patients underwent the IHCP without cimetidine (control group). The background factors and IHCP treatments of these two groups were nearly the same. Although the antitumour efficacy of the IHCP was not histologically different between the two groups, the histological analysis revealed that the peritoneo-serosal surface in the cimetidine group was protected against scald injury, compared with the control group. This finding suggests that pre-IHCP cimetidine is of great benefit for protecting the peritoneo-serosal surface from scald injury due to IHCP. |
| Databáze: | OpenAIRE |
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