Investigation on the carcinogenicity of emission condensate from brown coal-fired residential furnaces applied to mouse skin
| Autor: | J. Misfeld, G. Dettbarn, R. Deutsch-Wenzel, Gernot Grimmer, H. Brune, Jürgen Timm |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Air Pollutants
Cancer Research Flue gas Skin Neoplasms Time Factors Dose-Response Relationship Drug business.industry Chemistry Mice Inbred Strains Heating Mice chemistry.chemical_compound Coal Oncology Stove Environmental chemistry Mouse skin Benzo(a)pyrene Animals Pyrene Female business Brown coal Carcinogen |
| Zdroj: | Cancer Letters. 25:103-111 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(84)80032-4 |
| Popis: | Summary Flue gas condensate emitted from brown coal-fired stoves was tested in 3 dosages applied chronically to the skin of female CFLP mice twice a week over a period of 104 weeks. To answer the question which portion of the total carcinogenicity results from benzo[ a ]pyrene (BaP), this compound was taken as reference substance. The probit and Weibull analysis of the results showed a linear doseresponse relationship for both tumor incidences and tumor induction times. The amount of BaP in the emission condensate (0.593 mg/g condensate) contributes about 15% to the total carcinogenic effect of the brown coal flue gas condensate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|