Neuronal degeneration associated with sympathosensory plexuses in the trigeminal ganglia of aged mice that overexpress nerve growth factor
| Autor: | Michael D. Kawaja, Laura J. Smithson, Karmen M. Krol |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Genetically modified mouse
Aging Pathology medicine.medical_specialty Gene Expression Mice Transgenic 03 medical and health sciences 0302 clinical medicine Glial Fibrillary Acidic Protein Nerve Growth Factor medicine Animals 030304 developmental biology 0303 health sciences Ganglia Sympathetic Glial fibrillary acidic protein biology Tumor Necrosis Factor-alpha Satellite glial cell General Neuroscience Gene Expression Regulation Developmental Colocalization Immunohistochemistry Axons Nerve growth factor Trigeminal Ganglion nervous system Nerve Degeneration biology.protein Tumor necrosis factor alpha Neurology (clinical) Geriatrics and Gerontology 030217 neurology & neurosurgery Immunostaining Developmental Biology Sprouting |
| Zdroj: | Neurobiology of Aging. 35:2812-2821 |
| ISSN: | 0197-4580 |
| Popis: | Aberrant sympathetic sprouting is seen in the uninjured trigeminal ganglia of transgenic mice that ectopically express nerve growth factor under the control of the glial fibrillary acidic protein promoter. These sympathetic axons form perineuronal plexuses around a subset of sensory somata in 2- to 3-month-old transgenic mice. Here, we show that aged transgenic mice (i.e., 11–14 and 16–18 months old) have dystrophic sympathetic plexuses (i.e., increased densities of swollen axons), and that satellite glial cells, specifically those in contact with dystrophic plexuses in the aged mice display strong immunostaining for tumor necrosis factor alpha. The colocalization of dystrophic plexuses and reactive satellite glial cells in the aged mice coincides with degenerative features in the enveloped sensory somata. Collectively, these novel results show that, with advancing age, sympathetic plexuses undergo dystrophic changes that heighten satellite glial cell reactivity and that together these cellular events coincide with neuronal degeneration. |
| Databáze: | OpenAIRE |
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