Human leukocyte antigen–A, -B, -C, -DRB1 allele and haplotype frequencies in Americans originating from southern Europe: Contrasting patterns of population differentiation between Italian and Spanish Americans
| Autor: | Ruyan Yang, Jennifer Ng, Steven J. Mack, Carly Masaberg, Carolyn Katovich Hurley, Bin Tu |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Linkage disequilibrium
Immunology Population HLA-C Antigens Human leukocyte antigen Biology Balancing selection Linkage Disequilibrium White People Article Gene Frequency Leukocytes Humans Immunology and Allergy Registries Allele education Allele frequency Alleles Genetics education.field_of_study HLA-A Antigens Homozygote Haplotype HLA-DR Antigens Hispanic or Latino Sequence Analysis DNA General Medicine United States Genetics Population Haplotypes Italy HLA-B Antigens Population study HLA-DRB1 Chains |
| Zdroj: | Human Immunology. 72:144-149 |
| ISSN: | 0198-8859 |
| Popis: | High-resolution DNA sequencing was used to identify the human leukocyte antigen (HLA) –A, -B, -C, and -DRB1 alleles found in 552 individuals from the United States indicating Southern European (Italian or Spanish) heritage. A total of 46 HLA-A, 80 HLA-B, 32 HLA-C, and 50 DRB1 alleles were identified. Frequent alleles included A*02:01:01G (allele frequency = 0.26 in Italian Americans and 0.22 in Spanish Americans); B*07:02:01G (Italian Americans allele frequency = 0.11); B*44:03 (Spanish Americans allele frequency = 0.07); C*04:01:01G and C*07:01:01G (allele frequency = 0.13 and 0.16, respectively, in Italian Americans; 0.15 and 0.12, respectively, in Spanish Americans); and DRB1*07:01:01 (allele frequency = 0.12 in each population). The action of balancing selection was inferred at the HLA-B and -C loci in both populations. The A*01:01:01G-C*07:01:01G-B*08:01:01G-DRB1*03:01:01 haplotype was the most frequent A-C-B-DRB1 haplotype in Italian Americans (haplotype frequency = 0.049), and was the second most frequent haplotype in Spanish Americans (haplotype frequency = 0.021). A*29:02:01-C*16:01:01-B*44:03-DRB1*07:01:01 was the most frequent A-C-B-DRB1 in Spanish Americans (haplotype frequency = 0.023), and was observed at a frequency of 0.015 in Italian Americans. Pairwise F′ st values measuring the degree of differentiation between these Southern European American populations as well as European and European American populations suggest that Spanish Americans constitute a distinct subset of the European American population, most similar to Mexican Americans, whereas Italian Americans cannot be distinguished from the larger European American population. |
| Databáze: | OpenAIRE |
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