Adverse effects associated with bupropion therapeutic errors in adults reported to four United States Poison Centers
| Autor: | Henry A. Spiller, Jeanette D. Trella, Ashley N Webb, Martin Huecker, Michael C. Beuhler, Dalia Alwasiyah, Robert Bassett |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Tachycardia Pediatrics medicine.medical_specialty Poison Control Centers Drug-Related Side Effects and Adverse Reactions Context (language use) Toxicology Case review Poisons Seizures medicine Palpitations Humans In patient Adverse effect Bupropion Retrospective Studies business.industry General Medicine United States Exact test Female medicine.symptom business medicine.drug |
| Zdroj: | Clinical Toxicology. 60:623-627 |
| ISSN: | 1556-9519 1556-3650 |
| Popis: | CONTEXT Bupropion is a frequently used medication. Excessive doses may cause altered mental status, seizures, and dysrhythmias. There is a need for accurate estimate of seizure risk with therapeutic errors and determination if minor symptoms are harbingers of more severe effects. METHODS A retrospective review of adult, acute, unintentional therapeutic error, single substance bupropion ingestions with known outcome reported to four poison centers from January 1, 2004 to December 31, 2016. Data included age, gender, single error dose, total bupropion dose over 18 h, prior history of seizure, management site, observation time, occurrence of an out-of-hospital adverse event, "jittery"/anxious/agitated, tachycardia/palpitations, seizures, and dysrhythmias. We recorded the total bupropion dose over 18 h if known; otherwise, we used the single error dose. We compared means for parametric data. We used Fisher's exact test and Mann-Whitney for nonparametric data. RESULTS We identified 754 potential cases, of which 637 met inclusion criteria after case review. Median age was 42 years, and 76.1% were female. Cases were predominantly managed at home (56.2%). Outcomes were no effect (50.1%), minor (45.5%) and moderate (4.4%). The reported dose with no effect/minor outcome was 694 (±297) mg, and for moderate outcome was 1250 (±815) mg (p |
| Databáze: | OpenAIRE |
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