Stroma in normal and cancer wound healing
| Autor: | Vasilis Stavrinides, Eric Huet, Camille Jaroz, Alexandre de la Taille, Hayley C. Whitaker, Hoang Quy Nguyen, Y. Belkacemi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Stromal cell Biology Biochemistry Metastasis 03 medical and health sciences 0302 clinical medicine Stroma Fibrosis Neoplasms medicine Animals Humans Radiation Injuries Molecular Biology Extracellular Matrix Proteins Wound Healing Radiotherapy Cell Biology medicine.disease Crosstalk (biology) 030104 developmental biology Connective Tissue 030220 oncology & carcinogenesis Cancer cell Cancer research Cancer-Associated Fibroblasts Wound healing Signal Transduction |
| Zdroj: | The FEBS Journal. 286:2909-2920 |
| ISSN: | 1742-4658 1742-464X |
| DOI: | 10.1111/febs.14842 |
| Popis: | It is currently believed that stroma, the connective framework of biological tissues, plays a central role in normal wound healing and in cancer. In both these contexts, stromal cellular components such as activated fibroblasts interact with complex protein networks that include growth factors, structural protein or proteinases in order to initiate and sustain an extensive remodelling process. However, although this process is usually spatially and temporally self-limited, it is unregulated in the case of cancer and leads to uncontrolled cell proliferation and invasion within tissues, metastasis and therapeutic resistance. In this review, we outline the role of stroma in normal healing, cancer and post radiotherapy, with a particular focus on the crosstalk between normal or cancer cells and fibroblasts. Understanding these mechanisms is particularly important as several stromal components have been proposed as potential therapeutic targets. |
| Databáze: | OpenAIRE |
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