Phosphoglycerate mutase affects Stenotrophomonas maltophilia attachment to biotic and abiotic surfaces
| Autor: | Layla Ramos-Hegazy, Gregory G. Anderson, Shubham Chakravarty |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Transposable element Stenotrophomonas maltophilia 030106 microbiology Immunology Mutant Microbiology Bacterial Adhesion Article Phosphoglycerate mutase 03 medical and health sciences Bacterial Proteins Humans Gene Cells Cultured Abiotic component Phosphoglycerate Mutase biology Biofilm Wild type Epithelial Cells biochemical phenomena metabolism and nutrition biology.organism_classification 030104 developmental biology Infectious Diseases Biofilms Mutation Plastics |
| Zdroj: | Microbes Infect |
| ISSN: | 1769-714X |
| Popis: | Stenotrophomonas maltophilia biofilm formation is of increasing medical concern, particularly for lung infections. However, the molecular mechanisms facilitating the biofilm lifestyle in S. maltophilia are poorly understood. We generated and screened a transposon mutant library for mutations that lead to altered biofilm formation compared to wild type. One of these mutations, in the gene for glycolytic enzyme phosphoglycerate mutase (gpmA), resulted in impaired attachment on abiotic and biotic surfaces. As adherence to a surface is the initial step in biofilm developmental processes, our results reveal a unique factor that could affect S. maltophilia biofilm initiation and, possibly, subsequent development. |
| Databáze: | OpenAIRE |
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