From adrenarche to aging of adrenal zona reticularis: precocious female adrenopause onset
| Autor: | Caroline Busatta Vaz de Paula, Bonald C. Figueiredo, Cleber Machado-Souza, Juliana de Moura, Emanuelle Nunes-Souza, Guilherme Guilherme Vieira Cavalcante da Silva, Giovanna Silva Barbosa, José Renato S. Barbosa, Gislaine Custódio, Monalisa Castilho Mendes, Seigo Nagashima, Rayssa Danilow Fachin Donin, Lucia de Noronha, Luana Lenzi, Julia Belgrowicz Martins, Enzo Lalli, Mônica Evelise Silveira |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
phosphatase and tensin homolog
medicine.medical_specialty endocrine system Endocrinology Diabetes and Metabolism H&E stain Dehydroepiandrosterone 030209 endocrinology & metabolism dheas Overweight Pubarche lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Endocrinology dehydroepiandrosterone Internal medicine Internal Medicine medicine polycyclic compounds adrenopause skin and connective tissue diseases Pathological sulfated-dehydroepiandrosterone lcsh:RC648-665 business.industry Research Adrenarche adrenarche sulfateddehydroepiandrosterone dhea-s Cell loss pten medicine.anatomical_structure female 030220 oncology & carcinogenesis medicine.symptom business human activities Zona reticularis hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine Connections, Vol 9, Iss 12, Pp 1212-1220 (2020) Endocrine Connections |
| ISSN: | 2049-3614 |
| Popis: | Objective Adaptive changes in DHEA and sulfated-DHEA (DHEAS) production from adrenal zona reticularis (ZR) have been observed in normal and pathological conditions. Here we used three different cohorts to assess timing differences in DHEAS blood level changes and characterize the relationship between early blood DHEAS reduction and cell number changes in women ZR. Materials and methods DHEAS plasma samples (n = 463) were analyzed in 166 healthy prepubertal girls before pubarche ( Results We confirmed that overweight girls exhibited higher and earlier DHEAS levels and no difference was found compared with the average European and South American girls with a similar body mass index (BMI). Adrenopause onset threshold (AOT) defined as DHEAS blood levels 35% of the females >40 years old and associated with significantly reduced ZR cell number (based on PTEN and hematoxylin signals). ZR cell loss may in part account for lower DHEA/DHEAS expression, but most cells remain alive with lower DHEA/DHEAS biosynthesis. Conclusion The timely relation between significant reduction of blood DHEAS levels and decreased ZR cell number at the beginning of the 40s suggests that adrenopause is an additional burden for a significant number of middle-aged women, and may become an emergent problem associated with further sex steroids reduction during the menopausal transition. |
| Databáze: | OpenAIRE |
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