3D neural tissue models: From spheroids to bioprinting
| Autor: | Jia An, Sing Yian Chew, Chee Kai Chua, Alfred Xuyang Sun, Pei Zhuang |
|---|---|
| Přispěvatelé: | School of Chemical and Biomedical Engineering, School of Mechanical and Aerospace Engineering, Lee Kong Chian School of Medicine (LKCMedicine), A*STAR Genome Institute of Singapore, Singapore Centre for 3D Printing |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Computer science Biophysics Bioengineering 02 engineering and technology Neural tissues Models Biological Biomaterials 03 medical and health sciences Spheroids Cellular Humans Tissue Engineering Tissue Scaffolds Bioprinting Spheroid Tissue level 021001 nanoscience & nanotechnology Nerve Regeneration 3D Printing Engineering::Mechanical engineering [DRNTU] 030104 developmental biology Mechanics of Materials Ceramics and Composites 0210 nano-technology Neural regeneration Neuroscience Biomedical engineering |
| Zdroj: | Biomaterials. 154:113-133 |
| ISSN: | 0142-9612 |
| Popis: | Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great potential for both mechanistic and translational studies. In this paper, we review the recent developments in 3D in vitro neural tissue models, with a particular focus on the emerging bioprinted tissue structures. We draw on specific examples to describe the merits and limitations of each model, in terms of different applications. Bioprinting offers a revolutionary approach for constructing repeatable and controllable 3D in vitro neural tissues with diverse cell types, complex microscale features and tissue level responses. Further advances in bioprinting research would likely consolidate existing models and generate complex neural tissue structures bearing higher fidelity, which is ultimately useful for probing disease-specific mechanisms, facilitating development of novel therapeutics and promoting neural regeneration. NRF (Natl Research Foundation, S’pore) Accepted version |
| Databáze: | OpenAIRE |
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