Signals from the edges: The cortical hem and antihem in telencephalic development
| Autor: | Lakshmi Subramanian, Ryan Remedios, Shubha Tole, Ashwin S. Shetty |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Telencephalon
Review Biology Induction 03 medical and health sciences 0302 clinical medicine biology.animal medicine Animals Primordium 030304 developmental biology Homeodomain Proteins 0303 health sciences Hem Cerebrum Vertebrate Cell Biology Biological evolution Anatomy Biological Evolution Wnt Proteins Patterning Neuroepithelial cell Hippocampal organizer medicine.anatomical_structure Antihem Forebrain Neuroscience 030217 neurology & neurosurgery Transcription Factors Developmental Biology |
| Zdroj: | Seminars in Cell and Developmental Biology Seminars in Cell & Developmental Biology |
| ISSN: | 1084-9521 |
| Popis: | The early cortical primordium develops from a sheet of neuroepithelium that is flanked by distinct signaling centers. Of these, the hem and the antihem are positioned as longitudinal stripes, running rostro-caudally along the medial and lateral faces, respectively, of each telencepahlic hemisphere. In this review we examine the similarities and differences in how these two signaling centers arise, their roles in patterning adjacent tissues, and the cells and structures they contribute to. Since both the hem and the antihem have been identified across many vertebrate phyla, they appear to be part of an evolutionary conserved set of mechanisms that play fundamental roles in forebrain development. |
| Databáze: | OpenAIRE |
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