Both central and peripheral auditory systems are involved in salicylate-induced tinnitus in rats: a behavioral study
Autor: | Yongzhu Sun, Pengcheng Cui, Lining Feng, Zhi Liu, Haifeng Chang, Guanyin Chen |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Male
lcsh:Medicine Otology Audiology Rats Sprague-Dawley chemistry.chemical_compound Tinnitus Medicine and Health Sciences lcsh:Science Hearing Disorders Multidisciplinary Behavior Animal musculoskeletal neural and ocular physiology Low dose digestive oral and skin physiology Peripheral Neurology Behavioral Pharmacology Anesthesia Pattern Recognition Physiological behavior and behavior mechanisms medicine.symptom Salicylic Acid Injections Intraperitoneal psychological phenomena and processes Research Article medicine.medical_specialty Rat model Drinking Auditory nerves Research and Analysis Methods behavioral disciplines and activities Behavioral study medicine Evoked Potentials Auditory Brain Stem Animals Animal Models of Disease Latency (engineering) Cochlear Nerve Pharmacology business.industry Drinking Water lcsh:R Rats chemistry Otorhinolaryngology Acoustic Stimulation Animal Studies Conditioning Operant lcsh:Q business Microelectrodes Salicylic acid |
Zdroj: | PLoS ONE, Vol 9, Iss 9, p e108659 (2014) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Objective This study was designed to establish a low dose salicylate-induced tinnitus rat model and to investigate whether central or peripheral auditory system is involved in tinnitus. Methods Lick suppression ratio (R), lick count and lick latency of conditioned rats in salicylate group (120 mg/kg, intraperitoneally) and saline group were first compared. Bilateral auditory nerves were ablated in unconditioned rats and lick count and lick latency were compared before and after ablation. The ablation was then performed in conditioned rats and lick count and lick latency were compared between salicylate group and saline group and between ablated and unablated salicylate groups. Results Both the R value and the lick count in salicylate group were significantly higher than those in saline group and lick latency in salicylate group was significantly shorter than that in saline group. No significant changes were observed in lick count and lick latency before and after ablation. After ablation, lick count and lick latency in salicylate group were significantly higher and shorter respectively than those in saline group, but they were significantly lower and longer respectively than those in unablated salicylate group. Conclusion A low dose of salicylate (120 mg/kg) can induce tinnitus in rats and both central and peripheral auditory systems participate in the generation of salicylate-induced tinnitus. |
Databáze: | OpenAIRE |
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