Both central and peripheral auditory systems are involved in salicylate-induced tinnitus in rats: a behavioral study

Autor: Yongzhu Sun, Pengcheng Cui, Lining Feng, Zhi Liu, Haifeng Chang, Guanyin Chen
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
lcsh:Medicine
Otology
Audiology
Rats
Sprague-Dawley
chemistry.chemical_compound
Tinnitus
Medicine and Health Sciences
lcsh:Science
Hearing Disorders
Multidisciplinary
Behavior
Animal
musculoskeletal
neural
and ocular physiology
Low dose
digestive
oral
and skin physiology
Peripheral
Neurology
Behavioral Pharmacology
Anesthesia
Pattern Recognition
Physiological
behavior and behavior mechanisms
medicine.symptom
Salicylic Acid
Injections
Intraperitoneal
psychological phenomena and processes
Research Article
medicine.medical_specialty
Rat model
Drinking
Auditory nerves
Research and Analysis Methods
behavioral disciplines and activities
Behavioral study
medicine
Evoked Potentials
Auditory
Brain Stem
Animals
Animal Models of Disease
Latency (engineering)
Cochlear Nerve
Pharmacology
business.industry
Drinking Water
lcsh:R
Rats
chemistry
Otorhinolaryngology
Acoustic Stimulation
Animal Studies
Conditioning
Operant
lcsh:Q
business
Microelectrodes
Salicylic acid
Zdroj: PLoS ONE, Vol 9, Iss 9, p e108659 (2014)
PLoS ONE
ISSN: 1932-6203
Popis: Objective This study was designed to establish a low dose salicylate-induced tinnitus rat model and to investigate whether central or peripheral auditory system is involved in tinnitus. Methods Lick suppression ratio (R), lick count and lick latency of conditioned rats in salicylate group (120 mg/kg, intraperitoneally) and saline group were first compared. Bilateral auditory nerves were ablated in unconditioned rats and lick count and lick latency were compared before and after ablation. The ablation was then performed in conditioned rats and lick count and lick latency were compared between salicylate group and saline group and between ablated and unablated salicylate groups. Results Both the R value and the lick count in salicylate group were significantly higher than those in saline group and lick latency in salicylate group was significantly shorter than that in saline group. No significant changes were observed in lick count and lick latency before and after ablation. After ablation, lick count and lick latency in salicylate group were significantly higher and shorter respectively than those in saline group, but they were significantly lower and longer respectively than those in unablated salicylate group. Conclusion A low dose of salicylate (120 mg/kg) can induce tinnitus in rats and both central and peripheral auditory systems participate in the generation of salicylate-induced tinnitus.
Databáze: OpenAIRE
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