Global Brain Flexibility During Working Memory Is Reduced in a High-Genetic-Risk Group for Schizophrenia

Autor: Stavros I. Dimitriadis, Krish D. Singh, Michael Conlon O'Donovan, Derek K. Jones, David Edmund Johannes Linden, Thomas M. Lancaster, George Davey Smith, Michael John Owen, Jeremy Hall, Stanley Zammit, Katherine E. Tansey, Gavin Perry
Přispěvatelé: RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: MHeNs - R2 - Mental Health, School for Mental Health and Neuroscienc, RS: MHeNs - R3 - Neuroscience
Rok vydání: 2021
Předmět:
Male
Longitudinal study
Audiology
0302 clinical medicine
Medicine
genetics
Longitudinal Studies
population study
PSYCHIATRIC-DISORDERS
05 social sciences
imaging
Brain
Flexibility (personality)
Cognition
RECONFIGURATION
DYNAMIC FUNCTIONAL CONNECTIVITY
NETWORKS
Memory
Short-Term
Schizophrenia
FMRI
Population study
Female
TEST-RETEST RELIABILITY
medicine.symptom
COMMUNITY STRUCTURE
medicine.medical_specialty
DORSOLATERAL PREFRONTAL CORTEX
Cognitive Neuroscience
INEFFICIENCY
behavioral disciplines and activities
Article
050105 experimental psychology
03 medical and health sciences
brain flexibility
mental disorders
Humans
Genetic Predisposition to Disease
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Biological Psychiatry
Cognitive deficit
General linear model
business.industry
Working memory
temporal modularity
medicine.disease
schizophrenia
TASK
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Biol Psychiatry Cogn Neurosci Neuroimaging
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(12), 1176-1184. Elsevier
Dimitriadis, S I, Lancaster, T, Perry, G, Tansey, K, Jones, D K, Singh, K D, Zammit, S, Davey Smith, G, Hall, J, O'Donovan, M C, Owen, M J & Linden, D E 2021, ' Global Brain Flexibility During Working Memory is reduced in a High Genetic Risk Group for Schizophrenia ', Biological Psychiatry, vol. 6, no. 12, pp. 1176-1184 . https://doi.org/10.1016/j.bpsc.2021.01.007
ISSN: 2451-9022
Popis: BACKGROUND: Altered functional brain connectivity has been proposed as an intermediate phenotype between genetic risk loci and clinical expression of schizophrenia. Genetic high-risk groups of healthy subjects are particularly suited for the investigation of this proposition because they can be tested in the absence of medication or other secondary effects of schizophrenia. METHODS: Here, we applied dynamic functional connectivity analysis to functional magnetic resonance imaging data to reveal the reconfiguration of brain networks during a cognitive task. We recruited healthy carriers of common risk variants using the recall-by-genotype design. We assessed 197 individuals: 99 individuals (52 female, 47 male) with low polygenic risk scores (schizophrenia risk profile scores [SCZ-PRSs]) and 98 individuals (52 female, 46 male) with high SCZ-PRSs from both tails of the SCZ-PRS distribution from a genotyped population cohort, the Avon Longitudinal Study of Parents and Children (N = 8169). We compared groups both on conventional brain activation profiles, using the general linear model of the experiment, and on the neural flexibility index, which quantifies how frequent a brain region's community affiliation changes over experimental time. RESULTS: Behavioral performance and standard brain activation profiles did not differ significantly between groups. High SCZ-PRS was associated with reduced flexibility index and network modularity across n-back levels. The whole-brain flexibility index and that of the frontoparietal working memory network was associated with n-back performance. We identified a dynamic network phenotype related to high SCZ-PRS. CONCLUSIONS: Such neurophysiological markers can become important for the elucidation of biological mechanisms of schizophrenia and, particularly, the associated cognitive deficit.
Databáze: OpenAIRE
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