Trajectory-modulated hippocampal neurons persist throughout memory-guided navigation
| Autor: | William Mau, Samuel Levy, Evan A. Ruesch, David W. Sullivan, Michael E. Hasselmo, Nathaniel R. Kinsky |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Science General Physics and Astronomy Hippocampus Hippocampal formation Biology General Biochemistry Genetics and Molecular Biology Article Task (project management) Memory guided 03 medical and health sciences 0302 clinical medicine Calcium imaging Memory Animals Alternation (linguistics) lcsh:Science Probability Neurons Multidisciplinary Behavior Animal Working memory General Chemistry Mice Inbred C57BL 030104 developmental biology nervous system Splitter Trajectory Calcium lcsh:Q Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-16226-4 |
| Popis: | Trajectory-dependent splitter neurons in the hippocampus encode information about a rodent’s prior trajectory during performance of a continuous alternation task. As such, they provide valuable information for supporting memory-guided behavior. Here, we employed single-photon calcium imaging in freely moving mice to investigate the emergence and fate of trajectory-dependent activity through learning and mastery of a continuous spatial alternation task. In agreement with others, the quality of trajectory-dependent information in hippocampal neurons correlated with task performance. We thus hypothesized that, due to their utility, splitter neurons would exhibit heightened stability. We find that splitter neurons were more likely to remain active and retained more consistent spatial information across multiple days than other neurons. Furthermore, we find that both splitter neurons and place cells emerged rapidly and maintained stable trajectory-dependent/spatial activity thereafter. Our results suggest that neurons with useful functional coding exhibit heightened stability to support memory guided behavior. Trajectory-coding neurons in the hippocampus convey important information for performing memory tasks. Here, Kinsky et al. track long-term neural activity in the hippocampus to find that trajectory-coding emerges rapidly and remains stable across long time-scales. |
| Databáze: | OpenAIRE |
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