A Convenient, One-Step Synthesis of Benzyl (Ar) Ureas of the Type ArCH2NHCONHR from Ar and R1OCH2NHCONHR via Ureidoalkylation

Autor:	Champika Jayasinghe, F. Alex Meece, Gary Histand, Dennis H. Burns
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Aniline chemistry Ethanethiol Organic Chemistry Organic chemistry Phenol One-Step Phenols Ring (chemistry) Anisole Medicinal chemistry Chemical synthesis
Zdroj:	The Journal of Organic Chemistry. 74:3156-3159
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo900002n
Popis:	A method for the one-step C-ureidoalkylation of phenol, anisole, or aniline rings furnishing ArCH(2)NHCONHR (Ar = benzyl) products in moderate to good yields is described. With phenol ring systems, higher yields were attained when the reaction was worked up with an acidic ethanethiol addition to cleave any O-ureidoalkylation products that formed during the reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb5b63eb2a8e097cf3f5b9c3b566fb1 https://doi.org/10.1021/jo900002n Zobrazit plný text záznamu