Resting‐state functional connectivity in patients with a complex PTSD or complex dissociative disorder before and after inpatient trauma treatment
| Autor: | Ellert R. S. Nijenhuis, Yolanda R. Schlumpf, Silke Bachmann, Carina Klein, Lutz Jäncke |
|---|---|
| Přispěvatelé: | University of Zurich, Schlumpf, Yolanda R |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
clinical observation study
medicine.drug_class Neurosciences. Biological psychiatry. Neuropsychiatry Dissociative Disorders Electroencephalography dissociation Dissociative 050105 experimental psychology Dissociation (psychology) Cognitive reappraisal Stress Disorders Post-Traumatic 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neural Pathways 2802 Behavioral Neuroscience medicine Humans 0501 psychology and cognitive sciences functional brain network Default mode network Original Research Brain Mapping Inpatients medicine.diagnostic_test Resting state fMRI business.industry 10093 Institute of Psychology Functional connectivity 05 social sciences Trauma treatment Brain Magnetic Resonance Imaging complex trauma resting‐state medicine.symptom business 150 Psychology 030217 neurology & neurosurgery electroencephalography Clinical psychology RC321-571 |
| Zdroj: | Brain and Behavior, Vol 11, Iss 7, Pp n/a-n/a (2021) Brain and Behavior |
| ISSN: | 2162-3279 |
| Popis: | Introduction Recent research suggests that traumatized patients are characterized by disrupted resting‐state functional connectivity. We examined whether neural networks involved in resting‐state change over the course of a phase‐oriented inpatient treatment for complex traumatized and dissociative disorder patients. We also investigated associations between these network alterations and clinical symptoms and emotion regulation skills. Methods Pre‐ and post‐treatment, electroencephalography (EEG) was recorded during resting‐state in patients (n = 23) with a complex dissociative disorder (CDD) or complex posttraumatic stress disorder (cPTSD). Patients also completed clinical and emotion regulation questionnaires. To reduce variance in the collected data, patients were exclusively tested as one prototypical dissociative part referred to as Apparently Normal Part (ANP). Functional network connectivity was examined and compared with a matched healthy control group (n = 37), also measured twice. Results Prior to treatment and compared with controls, patients had a significantly lower functional connectivity strength within eyes‐open and eyes‐closed resting‐state networks in the theta and alpha frequency band. Following treatment, functional connectivity strength within these networks was comparable to the control group and comprised areas belonging to the default mode network (DMN) and prefrontal as well as anterior cingulate control regions. Treatment‐related network normalizations in the theta frequency band were associated with a self‐reported increase in the use of cognitive reappraisal strategies and reduction in emotion regulation difficulties. Conclusion Phase‐oriented trauma treatment can strengthen resting‐state network connectivity and can increase the capacity of complex traumatized and dissociative patients as ANP to handle emotional challenges effectively. We examined whether neural networks involved in resting‐state change over the course of an inpatient treatment for complex traumatized and dissociative disorder patients. Prior to treatment and compared with matched‐healthy controls, patients revealed a significantly lower functional network connectivity between regions belonging to the DMN and prefrontal and anterior cingulate areas. Trauma treatment normalized patients' networks, and these changes were associated with an enhanced emotion regulation capacity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|