Exercise and Dairy Protein have Distinct Effects on Indices of Liver and Systemic Lipid Metabolism
| Autor: | Hesham Shamshoum, Logan K. Townsend, David C. Wright, Shivam Gandhi, Jane Shearer, David M. Mutch, Raylene A. Reimer, Sarah K. Trottier, Paul J. LeBlanc |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Western blot Physical Conditioning Animal Internal medicine Casein Lipidomics medicine Animals Obesity 030212 general & internal medicine Nutrition and Dietetics medicine.diagnostic_test Triglyceride Chemistry Lipogenesis Lipid metabolism Metabolism Carbohydrate Lipid Metabolism Lipids Rats Milk Liver Dairy Products |
| Zdroj: | Obesity. 28:97-105 |
| ISSN: | 1930-739X 1930-7381 |
| Popis: | Objective This study aimed to explore the individual and combined effects of skim milk powder (SMP) and exercise on indices of systemic and liver lipid metabolism in male obese rats. Methods Rats were fed a high-fat (~ 40% kcal from fat), high-sugar diet for 8 weeks. At 12 weeks of age, rats were assigned to one of four weight-matched, isocaloric, high-fat, high-sugar groups for 6 weeks: (1) casein-sedentary, (2) casein-exercise, (3) SMP-sedentary, and (4) SMP-exercise. Nonfat SMP or casein was the sole protein source in the dairy and control casein diets, respectively. Exercise training occurred 5 d/wk for 60 minutes on a motorized treadmill. Whole-body metabolism was assessed by a Comprehensive Lab Animal Monitoring System. Lipidomics, Western blot, and polymerase chain reaction were used to assess markers of hepatic lipid metabolism. Results Exercise, but not SMP, altered the fatty acid composition of liver triglycerides, reduced indices of lipogenesis, and increased expression of genes linked to oxidative metabolism, in conjunction with increases in whole-body fat oxidation. SMP and exercise reduced plasma triglycerides in an additive manner. Conclusions These findings provide evidence that SMP and exercise exert distinct effects on whole-body and hepatic carbohydrate and lipid metabolism and that they could work in a synergistic manner to reduce serum triglyceride concentrations. |
| Databáze: | OpenAIRE |
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