Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment
| Autor: | Hong Ryang Kil, Sung-Churl Lee, Jung-Woo Rhim, Ji-Whan Han, Jae-Won Yu, Kyung-Yil Lee, Hyun-Mi Kang, Yu-Mi Seo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Lymphocyte Inflammation 030204 cardiovascular system & hematology Systemic inflammation Pediatrics Gastroenterology C-reactive protein 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine Coronary artery lesion medicine Hemoglobin biology Kawasaki disease business.industry Albumin lcsh:RJ1-570 lcsh:Pediatrics medicine.disease medicine.anatomical_structure Pediatrics Perinatology and Child Health biology.protein Original Article medicine.symptom business Artery |
| Zdroj: | Korean Journal of Pediatrics, Vol 61, Iss 5, Pp 160-166 (2018) Korean Journal of Pediatrics |
| ISSN: | 2092-7258 1738-1061 |
| Popis: | Purpose This study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients. Methods Clinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between patients with and without coronary artery lesions (CALs). For evaluation of the relationships across laboratory indices, patients with a fever duration of 5 days or 6 days were used (n=204). Results The mean fever duration was 6.6±2.3 days, and the proportions of patients with CALs was 19.3% (n=114). C-reactive proteins (CRPs) and neutrophil differential values were highest and hemoglobin, albumin, and lymphocyte differential values were lowest in the 6-day group. Patients with CALs had longer total fever duration, higher CRP and neutrophil differential values and lower hemoglobin and albumin values compared to patients without CALs. CRP, albumin, neutrophil differential, and hemoglobin values at the peak inflammation stage of KD showed positive or negative correlations each other. Conclusion The severity of systemic inflammation in KD was reflected in the laboratory values including CRP, neutrophil differential, albumin, and hemoglobin. Observing changes in these laboratory parameters by repeated examinations prior to the peak of inflammation in acute KD may aid in diagnosis of early-presenting KD patients. |
| Databáze: | OpenAIRE |
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